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Volume 24, Number 11—November 2018
Dispatch

Fatal Case of Diphtheria and Risk for Reemergence, Singapore

Yingqi LaiComments to Author , Parthasarathy Purnima, Marc Ho, Michelle Ang, Rama N. Deepak, Ka Lip Chew, Shawn Vasoo, Dimatatac F. Capulong, and Vernon Lee
Author affiliations: Ministry of Health, Singapore (Y. Lai, M. Ho, M. Ang, V. Lee); Khoo Teck Puat Hospital, Singapore (P. Purnima, R.N. Deepak); National Public Health Laboratory, Singapore (M. Ang); National University Hospital, Singapore (K.L. Chew); Tan Tock Seng Hospital, Singapore (S. Vasoo, D.F. Capulong)

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Figure 2

Core-genome single-nucleotide polymorphism (SNP) phylogeny of Corynebacterium diphtheriae isolate from a 23-year-old man who died from diphtheria (OTH-17-20; bold) and 4 publicly available ST50 genomes (TH1141, GenBank accession no. GCA_001723455.1; CMCTH1443, accession no. GCA_001981275.1; CMCTH1112, accession no. GCA_001981275.1; and CDCE8392, accession no. GCA_000255215.1) of isolates collected from hospitals in Singapore during 2013–2017. Phylogeny was deduced by alignment with Parsnp (http:

Figure 2. Core-genome single-nucleotide polymorphism (SNP) phylogeny of Corynebacterium diphtheriae isolate from a 23-year-old man who died from diphtheria (OTH-17-20; bold) and 4 publicly available ST50 genomes (TH1141, GenBank accession no. GCA_001723455.1; CMCTH1443, accession no. GCA_001981275.1; CMCTH1112, accession no. GCA_001981275.1; and CDCE8392, accession no. GCA_000255215.1) of isolates collected from hospitals in Singapore during 2013–2017. Phylogeny was deduced by alignment with Parsnp (http://harvest.readthedocs.io/en/latest/content/parsnp.html), a rapid core-genome multialignment tool for genome assemblies. Extracted SNPs were concatenated, and phylogeny was inferred as described in Figure 1. There were 26,785 positions in the final dataset. Numbers next to branches show bootstrap values calculated by using 1,000 reiterations. Scale bar indicates nucleotide substitutions per site. ST, sequence type.

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Page created: October 16, 2018
Page updated: October 16, 2018
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