Volume 24, Number 11—November 2018
Congenital Zika Virus Infection with Normal Neurodevelopmental Outcome, Brazil
Highlight and copy the desired format.
|EID||Lemos de Carvalho A, Brites C, Taguchi T, Pinho S, Campos G, Lucena R. Congenital Zika Virus Infection with Normal Neurodevelopmental Outcome, Brazil. Emerg Infect Dis. 2018;24(11):2128-2130. https://dx.doi.org/10.3201/eid2411.180883|
|AMA||Lemos de Carvalho A, Brites C, Taguchi T, et al. Congenital Zika Virus Infection with Normal Neurodevelopmental Outcome, Brazil. Emerging Infectious Diseases. 2018;24(11):2128-2130. doi:10.3201/eid2411.180883.|
|APA||Lemos de Carvalho, A., Brites, C., Taguchi, T., Pinho, S., Campos, G., & Lucena, R. (2018). Congenital Zika Virus Infection with Normal Neurodevelopmental Outcome, Brazil. Emerging Infectious Diseases, 24(11), 2128-2130. https://dx.doi.org/10.3201/eid2411.180883.|
We describe a case of a 20-month-old girl with probable congenital Zika virus infection and normal neurodevelopment, despite microcephaly and abnormal neuroimaging. This case raises questions about early prognostic markers and draws attention to the need for investigation in suspected Zika cases, even if the child’s early neurodevelopment is normal.
Zika virus is a mosquitoborne RNA virus (genus Flavivirus, family Flaviviridae) that was first isolated in 1947 from monkeys in the Zika Forest in Uganda (1). In November 2015, there was an outbreak of congenital microcephaly in the northeast states of Brazil (2). Further confirmation of this syndrome’s relationship with Zika virus infection during pregnancy was then possible (3). Congenital Zika syndrome has been recognized as a new clinical entity (4,5). Most published case series focus on the picture of severely affected infants (6,7). We describe a case of a child with probable congenital Zika virus infection whose neurodevelopment was normal, despite microcephaly and abnormal neuroimaging. The mother provided written informed consent for this report.
The patient, a girl, was born at 36 weeks’, 4 days’ gestation; Apgar scores were 8 at first minute and 9 at fifth minute. There was no family history of microcephaly, and the parents were phenotypically normal. The pregnancy occurred during Brazil’s Zika virus epidemic and the mother lived in Bahia, the state where the virus was first detected and one of the most affected areas. She was 27 years of age, in her third pregnancy, and had a history of rash at 12 weeks’ gestation, followed by fever, headache, arthralgia, and conjunctivitis. She recovered after 1 week, without a specific diagnosis. At 24 weeks’ gestation, a routine ultrasound exam detected microcephaly in the fetus. Testing for HIV, human T-lymphotropic virus, cytomegalovirus, toxoplasmosis, rubella, syphilis, and hepatitis B and C in the mother yielded negative results. She had no further complications except for high blood pressure detected 3 days before delivery, the discovery of which led to an elective cesarean section.
At birth, the infant’s weight was 2,496 g (−0.6 SD), length was 45 cm (−1.1 SD), and head circumference was 29.5 cm (−2.4 SD) (8). She had no neonatal complications and was breast-fed without difficulty. Test results were negative for chikungunya, dengue, rubella, toxoplasmosis, cytomegalovirus, parvovirus B19, and herpes virus I and II. However, serum testing (EuroImmun, Lubeck, Germany) showed positive results for Zika virus IgM. Results of biochemical analysis of cerebrospinal fluid, abdominal ultrasound, and neonatal metabolic screening were all normal, as were ophthalmologic and auditory evaluations. Transfontanellar ultrasound showed focal calcification in basal ganglia that was more pronounced in the right hemisphere. Results of cerebral computed tomography conducted during the neonatal period showed mild craniofacial disproportion, slightly decreased brain volume, and small calcifications in the right nucleocapsular area and around the left thalamus.
In January 2016, at 6 months of age, the patient entered a neurorehabilitation program, during which she reached normal achievement of developmental milestones. Further investigation included a videoelectroencephalogram and auditory and visual evoked potentials; results were all normal. We diagnosed probable congenital Zika virus infection, considering the gestational history, congenital microcephaly, positive serologic test results, and neuroradiological findings, which were mild but consistent with Zika virus infection. A follow-up cerebral scan performed at 7 months of age showed mild calcifications at the right lenticular nucleus and posterior arm of the left internal capsule (Figure).
The patient started to walk independently at 13 months of age, and her gait pattern did not show any abnormality. We performed a follow-up assessment at 20 months of age. Neurologic examination was normal, except for microcephaly (head circumference 42.5 cm, −3 SD) (9). Weight was within reference range (8.7 kg, between −1 and −2 SD), but length was below reference values (74 cm, between −2 and −3 SD). The child was otherwise healthy. We performed developmental evaluation using Bayley-III Scales of Infant Development (10). All composite scores were within average classification (Technical Appendix).
Neurodevelopment is a dynamic process that depends on the interaction between neurobiological and environmental factors. Children initially developing within the expected range for their age group may experience a slowdown as demands of neurodevelopment become more extensive. We cannot make inferences about long-term prognosis from the patient’s condition at 20 months of age. Developmental evolution should be determined prospectively, using the same instrument so that results can be compared over time.
This report has 2 main limitations. First, molecular confirmation of Zika virus infection in the mother or the child was not possible. Second, we did not perform PCR or culture for cytomegalovirus. Nevertheless, the child’s Zika virus IgM was positive in the neonatal period, and her mother’s clinical symptoms suggested Zika virus infection during pregnancy, which occurred during the Zika virus epidemic in Brazil, in one of the most affected areas.
This case may indicate a broader spectrum in congenital Zika syndrome, raising questions about early prognostic markers. Our findings draw attention to the need for detailed evaluation even for typically developing children with possible congenital Zika virus infection who receive medical attention later.
Dr. Carvalho is a pediatrician at the Child Rehabilitation Center of SARAH Network of Rehabilitation Hospitals, Salvador Unit. She is currently a master’s degree student at the Postgraduate Program in Medicine and Health, Federal University of Bahia, Bahia, Brazil. Her primary clinical practice and research interests are in cerebral palsy and congenital Zika virus infection.
We thank Silvia Ines Sardi for technical contributions on Zika serology performance.
No external funding was used for this study. G.C. received a “Zika fast track grant” provided by Coordination for the Improvement of Higher Education Personnel (CAPES), Brazil, to perform ELISA testing for Zika virus in the neonatal period. This institution had no role in study design, data collection and analysis, decision to publish, or preparation of this manuscript. The other authors have no financial disclosures relevant to this article.
- Dick GWA, Kitchen SF, Haddow AJ. Zika virus. I. Isolations and serological specificity. Trans R Soc Trop Med Hyg. 1952;46:509–20.
- Pan American Health Organization; World Health Organization. Epidemiological update: Neurological syndrome, congenital anomalies, and Zika virus infection. 2016 Jan 17 [cited 2018 Sep 19]. https://www.paho.org/hq/dmdocuments/2016/2016-jan-17-cha-epi-update-zika-virus.pdf
- de Araújo TVB, Ximenes RAA, Miranda-Filho DB, Souza WV, Montarroyos UR, de Melo APL, et al.; investigators from the Microcephaly Epidemic Research Group; Brazilian Ministry of Health; Pan American Health Organization; Instituto de Medicina Integral Professor Fernando Figueira; State Health Department of Pernambuco. Association between microcephaly, Zika virus infection, and other risk factors in Brazil: final report of a case-control study. Lancet Infect Dis. 2018;18:328–36.
- Del Campo M, Feitosa IML, Ribeiro EM, Horovitz DDG, Pessoa ALS, França GVA, et al.; Zika Embryopathy Task Force-Brazilian Society of Medical Genetics ZETF-SBGM. The phenotypic spectrum of congenital Zika syndrome. Am J Med Genet A. 2017;173:841–57.
- Moore CA, Staples JE, Dobyns WB, Pessoa A, Ventura CV, Fonseca EB, et al. Characterizing the pattern of anomalies in congenital Zika syndrome for pediatric clinicians. JAMA Pediatr. 2017;171:288–95.
- Schuler-Faccini L, Ribeiro EM, Feitosa IML, Horovitz DDG, Cavalcanti DP, Pessoa A, et al.; Brazilian Medical Genetics Society–Zika Embryopathy Task Force. Possible association between Zika virus infection and microcephaly—Brazil, 2015. MMWR Morb Mortal Wkly Rep. 2016;65:59–62.
- Moura da Silva AA, Ganz JSS, Sousa PD, Doriqui MJR, Ribeiro MRC, Branco MD, et al. Early growth and neurologic outcomes of infants with probable congenital Zika virus syndrome. Emerg Infect Dis. 2016;22:1953–6.
- Villar J, Cheikh Ismail L, Victora CG, Ohuma EO, Bertino E, Altman DG, et al.; International Fetal and Newborn Growth Consortium for the 21st Century (INTERGROWTH-21st). International standards for newborn weight, length, and head circumference by gestational age and sex: the Newborn Cross-Sectional Study of the INTERGROWTH-21st Project. Lancet. 2014;384:857–68. https://doi.org/10.1016/S0140-6736(14)60932-6
- World Health Organization Multicentre Growth Reference Study Group. WHO child growth standards: length/height-for-age, weight-for-age, weight-for-length, weight-for-height, and body mass index-for-age: methods and development. Geneva: The Organization; 2006 [cited 2018 Aug 14]. http://www.who.int/childgrowth/standards/technical_report/en
- Bayley N. Bayley scales of infant and toddler development. 3rd ed. San Antonio (TX, USA); Psychological Corp.; 2005.
FigureCite This Article
Original Publication Date: 9/27/2018
- Page created: October 17, 2018
- Page last updated: October 17, 2018
- Page last reviewed: October 17, 2018
- Centers for Disease Control and Prevention,
National Center for Emerging and Zoonotic Infectious Diseases (NCEZID)
Office of the Director (OD)