Volume 24, Number 4—April 2018
Research Letter
Intensive Care Admissions for Severe Chikungunya Virus Infection, French Polynesia
Adrien Koeltz
, Stephane Lastere, and Sylvain Jean-Baptiste
, Stephane Lastere, and Sylvain Jean-Baptiste
Table
Clinical and laboratory characteristics of 64 patients with chikungunya virus infection admitted into the intensive care department, French Polynesia, 2014–2015*
| Characteristic | Result |
|---|---|
| Baseline | |
| Median age, y (IQR) | 62 (49–71) |
| Sex, no. (%) | |
| M | 37 (58) |
| F | 27 (42) |
| Preexisting disease, no. (%) | |
| Hypertension | 37 (58) |
| Diabetes mellitus | 22 (34) |
| Chronic renal failure | 15 (23) |
| Chronic heart failure | 12 (19) |
| Chronic liver disease | 3 (5) |
| None |
15 (23) |
| Simplified Acute Physiology Score (IQR) |
48 (28.5–68.5) |
| Chikungunya diagnosis, no. (%) | |
| By reverse transcription PCR | 42 (66) |
| By IgM | 26 (41) |
| By reverse transcription PCR and IgM |
4 (6) |
| Finding at admission | |
| Organ failure,† no. (%) | |
| Hemodynamic | 40 (63) |
| Renal | 30 (47) |
| Neurologic | 20 (31) |
| Respiratory | 33 (52) |
| Hepatic | 16 (25) |
| Hematologic | 9 (14) |
| Laboratory‡ | |
| Leukocyte count, cells/m3, median (IQR) | 11,600 (7,200–15,200) |
| Lymphocyte count, cells/m3, median (IQR) | 1,000 (600–1,500) |
| Lymphopenia, <1,000 cells/m3 (% of patients) | 36 (56) |
| Platelet count, cells/m3, median (IQR) | 155,000 (79–208) |
| Platelet count, <150,000 cells/m3 (% of patients) | 34,000 (53) |
| Creatinine, μmol/L, median (IQR) | 132 (79–184) |
| Creatine phosphokinase, mmol/L, median (IQR) | 222 (124–1,160) |
| Alanine aminotransferase, UI/L, median (IQR) | 35 (19–76) |
| C-reactive protein, mg/L, median (IQR) | 10.6 (2.8–18.3) |
| Procalcitonin, μg/L, median (IQR) | 1.72 (0.42–18.3) |
| Lactate, mmol/L, median (IQR) |
2.6 (1.1–5.4) |
| Chikungunya reverse transcription PCR‡ | |
| Viral load in serum, log10 copies/mL (IQR) | 7.52 (3.47–9.39) |
| Viral load in cerebrospinal fluid,§ log10 copies/mL (IQR) |
4.18 (3.86–4.26) |
| Outcome variable | |
| ICU length of stay, d, median (IQR) | 3 (2–7) |
| Crude intensive care unit deaths, no (%) | 18 (28) |
*IQR, interquartile range.
†Organ failure is defined according to a Sequential Organ Failure Assessment score >3 for each organ.
‡Blood samples during the first 24 h. Reference values are as follows: leukocytes, 4.0–10.0 × 103 cells/mm3; lymphocytes, 1.5–3.4 × 103 cells/mm3; platelets, 150–400 × 103/mm3; creatinine, 0.56–1.0 mg/dL; creatine phosphokinase, 0–130 U/L; alanine aminotransferase, 0–35 U/L; C-reactive protein, <5 mg/L; procalcitonin, <0.5 ng/mL; lactate, 5–15 mg/dL.
§Virus load was positive for 5 of the 9 cerebrospinal fluid samples.
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Page updated: March 16, 2018
Page reviewed: March 16, 2018
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