Volume 24, Number 4—April 2018
Dispatch
Imipenem Resistance in Clostridium difficile Ribotype 017, Portugal
Table 2
Gene in M68 genome* | Genome position* | Nucleotide in M68 | Nucleotide change† | Amino acid change† | Gene product |
---|---|---|---|---|---|
RS02665 | 512416 | C | C578T | Ala193Val‡ | Multidrug ATP-binding cassette transporter permease, associated with antimicrobial drug resistance |
RS04280/pbp1 | 905394 | G | G1663A | Ala555Thr‡ | Penicillin-binding transpeptidase |
RS04935 | 1048151 | C | T1010C | Ile337Thr‡ | 3-Isopropylmalate dehydratase large subunit |
RS05670/pbp3 | 1221182 | G | A2162C | Tyr721Ser‡ | Penicillin-binding protein |
RS07765 | 1666351 | G | G214T | Gly72§ | Hypothetical protein |
RS07795/hisB | 1671129 | T | T209C | Ile70Thr‡ | Imidazoleglycerol-phosphate dehydratase |
RS07810 | 1673280 | T | C474T | Ala158Ala | Imidazoleglycerol-phosphate synthase cyclase subunit |
RS08415 | 1792079 | G | A241G | Lys81Glu‡ | Hypothetical protein (domain of MerR-like transcriptional regulators) |
RS08810 | 1882950 | C | C420T | Asp140Asp | Flavodoxin |
RS14235 | 3083548 | G | G421T | Gly141§ | Haloacid dehalogenase |
RS18530 | 4054525 | C | C220T | Gln74§ | S-adenosyl methionine–dependent methyltransferase |
RS19130/gyrA | 4174650 | C | C245T | Thr82Ile‡ | DNA gyrase subunit A |
RS19545 | 4255124 | C | C400T | His134Tyr‡ | Phage portal, SPP1 Gp6-like family protein |
*Relative to the annotation of the C. difficile M68 genome (GenBank accession no. NC_017175).
†Changes observed between imipenem-resistant and imipenem-susceptible isolates.
‡Nonsynonymous mutations.
§Mutations leading to putative protein truncation.
Page created: March 16, 2018
Page updated: March 16, 2018
Page reviewed: March 16, 2018
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.