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Volume 24, Number 4—April 2018
Research

Emerging Coxsackievirus A6 Causing Hand, Foot and Mouth Disease, Vietnam

Nguyen To Anh, Le Nguyen Truc Nhu, Hoang Minh Tu Van, Nguyen Thi Thu Hong, Tran Tan Thanh, Vu Thi Ty Hang, Nguyen Thi Han Ny, Lam Anh Nguyet, Tran Thi Lan Phuong, Le Nguyen Thanh Nhan, Nguyen Thanh Hung, Truong Huu Khanh, Ha Manh Tuan, Ho Lu Viet, Nguyen Tran Nam, Do Chau Viet, Phan Tu Qui, Bridget Wills, Sarawathy Sabanathan, Nguyen Van Vinh Chau, Louise Thwaites, H. Rogier van Doorn, Guy Thwaites, Maia A. Rabaa, and Le Van TanComments to Author 
Author affiliations: Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam (N.T. Anh, L.N.T. Nhu, H.M.T. Van, N.T.T. Hong, T.T. Thanh, V.T.T. Hang, N.T.H. Ny, L.A. Nguyet, B. Wills, S. Sabanathan, L. Thwaites, H.R. van Doorn, G. Thwaites, M.A. Rabaa, L.V. Tan); Hospital for Tropical Diseases, Ho Chi Minh City (T.T.L. Phuong, P.T. Qui, N.V.V. Chau); Children’s Hospital 1, Ho Chi Minh City (L.N.T. Nhan, N.T. Hung, T.H. Khanh); Children’s Hospital 2, Ho Chi Minh City (H.M. Tuan, H.L. Viet, N.T. Nam, D.C. Viet); University of Oxford, Oxford, United Kingdom (L. Thwaites, H.R. van Doorn, G. Thwaites, M.A. Rabaa)

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Figure 4

Skyline plots depicting the relative genetic diversity of CV-A6 over time. A) Result obtained from the analysis of viral capsid protein 1 sequences of global strains; B) result obtained from the analysis of complete coding sequences of Vietnam strains. Blue shading indicates 95% highest posterior density interval. Arrows in panel A indicate worldwide CV-A6 outbreaks and associated fluctuations in relative genetic diversity ; map (obtained from https://mapchart.net) illustrates the countries in w

Figure 4. Skyline plots depicting the relative genetic diversity of CV-A6 over time. A) Result obtained from the analysis of viral capsid protein 1 sequences of global strains; B) result obtained from the analysis of complete coding sequences of Vietnam strains. Blue shading indicates 95% highest posterior density interval. Arrows in panel A indicate worldwide CV-A6 outbreaks and associated fluctuations in relative genetic diversity ; map (obtained from https://mapchart.net) illustrates the countries in which CV-A6–associated HFMD outbreaks have been recorded to date (3). No sequences from Cuba, Singapore, or the United States fulfilled the selection criteria for the skyline plot and phylogenetic analyses (see Methods section). CV, coxsackievirus.

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Page created: March 16, 2018
Page updated: March 16, 2018
Page reviewed: March 16, 2018
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