Volume 24, Number 4—April 2018
Research
Emerging Coxsackievirus A6 Causing Hand, Foot and Mouth Disease, Vietnam
Nguyen To Anh, Le Nguyen Truc Nhu, Hoang Minh Tu Van, Nguyen Thi Thu Hong, Tran Tan Thanh, Vu Thi Ty Hang, Nguyen Thi Han Ny, Lam Anh Nguyet, Tran Thi Lan Phuong, Le Nguyen Thanh Nhan, Nguyen Thanh Hung, Truong Huu Khanh, Ha Manh Tuan, Ho Lu Viet, Nguyen Tran Nam, Do Chau Viet, Phan Tu Qui, Bridget Wills, Sarawathy Sabanathan, Nguyen Van Vinh Chau, Louise Thwaites, H. Rogier van Doorn, Guy Thwaites, Maia A. Rabaa, and Le Van Tan
Table
Demographics and clinical severity grades for patients with CV-A6–associated HFMD, Vietnam, 2011–2015*
| Demographics | Total, n = 510 | 2011–2012, n = 76 | 2013–2015, n = 434 | Group 1, patients with CDS included in analyses, n = 98 | Group 2, patients excluded from phylogenetic analyses, n = 412 |
|---|---|---|---|---|---|
| Sex | |||||
| M | 330 (64.7) | 50 (65.8) | 280 (64.5) | 68 (69.4) | 262 (63.6) |
| F |
180 (35.3) |
26 (34.2) |
154 (35.5) |
30 (30.6) |
150 (36.4) |
| Age, mo | |||||
| Median | 16.07 | 15.23 | 16.18 | 15.52 | 16.17 |
| IQR |
11.57–22.46 |
9.83–24.74 |
11.85–22.43 |
10.68–24.48 |
11.71–22.41 |
| Highest grade | |||||
| 1 | 188 (36.8) | 0 | 188 (43.3) | 39 (39.8) | 149 (36.1) |
| 2a | 229 (44.9) | 0 | 229 (52.8) | 26 (26.5) | 203 (49.3) |
| 2b1 | 81 (15.9) | 68 (89.5) | 13 (3.0) | 30 (30.6) | 51 (12.4) |
| 2b2 | 5 (1.0) | 2 (2.6) | 3 (0.7) | 1 (1.0) | 4 (1.0) |
| 3 |
7 (1.4) |
6 (7.9) |
1 (0.2) |
2 (2.0) |
5 (1.2) |
| Location | |||||
| HCMC | 327 (64.1) | 54 (71.1) | 273 (62.9) | 57 (58.2) | 270 (65.5) |
| Mekong Delta† | 89 (17.5) | 17 (22.4) | 72 (16.6) | 21 (21.4) | 68 (16.5) |
| Southeast‡ | 88 (17.3) | 5 (6.6) | 83 (19.1) | 20 (20.4) | 68 (16.5) |
| Others§ | 6 (1.1) | 0 | 6 (1.4) | 0 | 6 (1.5) |
*Values are no. (%) patients except as indicated. CV, coxsackievirus; HCMC, Ho Chi Minh City; HFMD, hand, foot and mouth disease; IQR, interquartile range.
†Long An, Can Tho, Tien Giang, Kien Giang, Dong Thap, and Hau Giang provinces.
‡Tay Ninh, Dong Nai, Binh Duong, Binh Phuoc, Ba Ria, and Vung Tau provinces.
§Binh Thuan (n = 2), Hai Duong (n = 1), Quang Ngai (n = 1), Khanh Hoa (n = 1), and Thanh Hoa (n = 1).
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