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Volume 24, Number 4—April 2018

Research

Influenza A(H7N9) Virus Antibody Responses in Survivors 1 Year after Infection, China, 2017

Mai-Juan Ma1, Cheng Liu1, Meng-Na Wu, Teng Zhao, Guo-Lin Wang, Yang Yang, Hong-Jing Gu, Peng-Wei Cui, Yuan-Yuan Pang, Ya-Yun Tan, Hui Hang, Bao Lin, Jiang-Chun Qin, Li-Qun FangComments to Author , Wu-Chun CaoComments to Author , and Li-Ling ChengComments to Author 
Author affiliations: Beijing Institute of Microbiology and Epidemiology, Beijing, China (M.-J. Ma, M.-N. Wu, T. Zhao, G.-L. Wang, H.-J. Gu, L.-Q. Fang, W.-C. Cao); University of Florida, Gainesville, Florida, USA (Y. Yang); Suzhou Municipal Center for Disease Control and Prevention, Suzhou, China (C. Liu, P.-W. Cui, Y.-Y. Pang, Y.-Y. Tan, H. Hang, B. Lin, J.-C. Qin, L.-L. Chen)

Main Article

Figure 3

Testing of convalescent-phase serum transfer as potential protection against influenza A(H7N9) virus infection. Mice received 40 μL of patient serum intravenously 12 hours before H7N9 virus infection. A) IgG titers from mouse serum samples collected 1 h before infection. B–D) Relationships between IgG, HI, and MN titers in human serum and IgG titer in mouse recipients of transferred serum. E) Virus titers in homogenized mouse lungs at day 3 after infection (mean ± SE). F) Relationship between Ig

Figure 3. Testing of convalescent-phase serum transfer as potential protection against influenza A(H7N9) virus infection. Mice received 40 μL of patient serum intravenously 12 hours before H7N9 virus infection. A) IgG titers from mouse serum samples collected 1 h before infection. B–D) Relationships between IgG, HI, and MN titers in human serum and IgG titer in mouse recipients of transferred serum. E) Virus titers in homogenized mouse lungs at day 3 after infection (mean ± SE). F) Relationship between IgG titer in mouse serum samples and viral titers in mouse lung samples. HD, healthy donor; HI, hemagglutination inhibition; LOD, limit of detection; MN, microneutralization; S, serum; TCID50, 50% tissue culture infectious dose.

Main Article

1These authors contributed equally to this article.

Page created: June 22, 2018
Page updated: June 22, 2018
Page reviewed: June 22, 2018
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