, Guus Koch, Rene Heutink, Frank Harders, D.P. Edwin Vries, Cynthia Ho, Alex Bossers, and Armin Elbers
Figure 2. Schematic representation of the HPAI H5N6 reassortant virus detected in the Netherlands. Two variants of HPAI H5N8 were detected in 2016; they have different PA gene segments, called PA I and PA II. The novel virus evolved from H5N8 viruses having a PA II gene segment, but obtained both novel NA and PB2 gene segments. The H5N6 viruses detected in Greece, Japan, and Taiwan have evolved from H5N8 viruses that have a PA I gene segment and have an N6 segment similar to the virus detected in the Netherlands. HPAI, highly pathogenic avian influenza; PB, polymerase basic; PA, polymerase acidic; HA, hemagglutinin; NP, nucleoprotein; NA, neuraminidase; MP, matrix protein; NS, nonstructural protein.