Volume 24, Number 4—April 2018
Highlight and copy the desired format.
|EID||Ruiz J. Etymologia: TEM. Emerg Infect Dis. 2018;24(4):709. https://dx.doi.org/10.3201/eid2404.et2404|
|AMA||Ruiz J. Etymologia: TEM. Emerging Infectious Diseases. 2018;24(4):709. doi:10.3201/eid2404.et2404.|
|APA||Ruiz, J. (2018). Etymologia: TEM. Emerging Infectious Diseases, 24(4), 709. https://dx.doi.org/10.3201/eid2404.et2404.|
In 1965, the transferability of ampicillin resistance was reported, and the plasmid-encoded mechanism of resistance for 2 Salmonella sp. isolates from the United Kingdom and 1 Escherichia coli isolate from Greece was determined. Resistance (R) factors from Salmonella sp. isolates were designated R1818 and R7268 (R7268 encoding the current TEM-1). The E. coli isolate and its plasmid were named TEM (encoding the current TEM-2) because the isolate was recovered from a feces culture of an Athenian patient named Temoniera in 1963.
β-lactam resistance is a problem worldwide; >2,000 β-lactamases are currently identified. Of these β-lactamases, >200 enzymes are classified within TEM family, including extended-spectrum β-lactamases (ESBLs). However, the original TEM-1 and TEM-2 hydrolyze only penicillin derivatives.
- Ambler RP, Scott GK. Partial amino acid sequence of penicillinase coded by Escherichia coli plasmid R6K. Proc Natl Acad Sci U S A. 1978;75:3732–6.
- Anderson ES, Datta N. Resistance to penicillins and its transfer in Enterobacteriaceae. Lancet. 1965;1:407–9.
- Bonomo RA. β-lactamases: a focus on current challenges. Cold Spring Harb Perspect Med. 2017;7:a025239.
- Bush K, Jacoby GA, Medeiros AA. A functional classification scheme for beta-lactamases and its correlation with molecular structure. Antimicrob Agents Chemother. 1995;39:1211–33.
- Datta N, Kontomichalou P. Penicillinase synthesis controlled by infectious R factors in Enterobacteriaceae. Nature. 1965;208:239–41.
- Kontomichalou P. Studies on resistance transfer factors. Pathol Microbiol (Basel). 1967;30:71–93.
- Medeiros AA. β-lactamases. Br Med Bull. 1984;40:18–27.
- Sutcliffe JG. Nucleotide sequence of the ampicillin resistance gene of Escherichia coli plasmid pBR322. Proc Natl Acad Sci U S A. 1978;75:3737–41.
- Page created: March 19, 2018
- Page last updated: March 19, 2018
- Page last reviewed: March 19, 2018
- Centers for Disease Control and Prevention,
National Center for Emerging and Zoonotic Infectious Diseases (NCEZID)
Office of the Director (OD)