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Volume 24, Number 4—April 2018


Etymologia: TEM

Joaquim RuizComments to Author 

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EID Ruiz J. Etymologia: TEM. Emerg Infect Dis. 2018;24(4):709.
AMA Ruiz J. Etymologia: TEM. Emerging Infectious Diseases. 2018;24(4):709. doi:10.3201/eid2404.et2404.
APA Ruiz, J. (2018). Etymologia: TEM. Emerging Infectious Diseases, 24(4), 709.


In 1965, the transferability of ampicillin resistance was reported, and the plasmid-encoded mechanism of resistance for 2 Salmonella sp. isolates from the United Kingdom and 1 Escherichia coli isolate from Greece was determined. Resistance (R) factors from Salmonella sp. isolates were designated R1818 and R7268 (R7268 encoding the current TEM-1). The E. coli isolate and its plasmid were named TEM (encoding the current TEM-2) because the isolate was recovered from a feces culture of an Athenian patient named Temoniera in 1963.

β-lactam resistance is a problem worldwide; >2,000 β-lactamases are currently identified. Of these β-lactamases, >200 enzymes are classified within TEM family, including extended-spectrum β-lactamases (ESBLs). However, the original TEM-1 and TEM-2 hydrolyze only penicillin derivatives.



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Cite This Article

DOI: 10.3201/eid2404.et2404

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Table of Contents – Volume 24, Number 4—April 2018


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Joaquim Ruiz, PO Box 16, 08214 Badia del Valles, Spain

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