Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 24, Number 4—April 2018
Etymologia

Etymologia: TEM

Cite This Article

TEM

In 1965, the transferability of ampicillin resistance was reported, and the plasmid-encoded mechanism of resistance for 2 Salmonella sp. isolates from the United Kingdom and 1 Escherichia coli isolate from Greece was determined. Resistance (R) factors from Salmonella sp. isolates were designated R1818 and R7268 (R7268 encoding the current TEM-1). The E. coli isolate and its plasmid were named TEM (encoding the current TEM-2) because the isolate was recovered from a feces culture of an Athenian patient named Temoniera in 1963.

β-lactam resistance is a problem worldwide; >2,000 β-lactamases are currently identified. Of these β-lactamases, >200 enzymes are classified within TEM family, including extended-spectrum β-lactamases (ESBLs). However, the original TEM-1 and TEM-2 hydrolyze only penicillin derivatives.

Top

References

  1. Ambler  RP, Scott  GK. Partial amino acid sequence of penicillinase coded by Escherichia coli plasmid R6K. Proc Natl Acad Sci U S A. 1978;75:37326. DOIPubMedGoogle Scholar
  2. Anderson  ES, Datta  N. Resistance to penicillins and its transfer in Enterobacteriaceae. Lancet. 1965;1:4079. DOIPubMedGoogle Scholar
  3. Bonomo  RA. β-lactamases: a focus on current challenges. Cold Spring Harb Perspect Med. 2017;7:a025239. DOIPubMedGoogle Scholar
  4. Bush  K, Jacoby  GA, Medeiros  AA. A functional classification scheme for beta-lactamases and its correlation with molecular structure. Antimicrob Agents Chemother. 1995;39:121133. DOIPubMedGoogle Scholar
  5. Datta  N, Kontomichalou  P. Penicillinase synthesis controlled by infectious R factors in Enterobacteriaceae. Nature. 1965;208:23941. DOIPubMedGoogle Scholar
  6. Kontomichalou  P. Studies on resistance transfer factors. Pathol Microbiol (Basel). 1967;30:7193.PubMedGoogle Scholar
  7. Medeiros  AA. β-lactamases. Br Med Bull. 1984;40:1827. DOIPubMedGoogle Scholar
  8. Sutcliffe  JG. Nucleotide sequence of the ampicillin resistance gene of Escherichia coli plasmid pBR322. Proc Natl Acad Sci U S A. 1978;75:373741. DOIPubMedGoogle Scholar

Top

Cite This Article

DOI: 10.3201/eid2404.et2404

Related Links

Top

Table of Contents – Volume 24, Number 4—April 2018

EID Search Options
presentation_01 Advanced Article Search – Search articles by author and/or keyword.
presentation_01 Articles by Country Search – Search articles by the topic country.
presentation_01 Article Type Search – Search articles by article type and issue.

Top

Comments

Please use the form below to submit correspondence to the authors or contact them at the following address:

Joaquim Ruiz, PO Box 16, 08214 Badia del Valles, Spain

Send To

10000 character(s) remaining.

Top

Page created: March 19, 2018
Page updated: March 19, 2018
Page reviewed: March 19, 2018
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external