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Volume 24, Number 4—April 2018
Etymologia

Etymologia: TEM

Joaquim RuizComments to Author 

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TEM

In 1965, the transferability of ampicillin resistance was reported, and the plasmid-encoded mechanism of resistance for 2 Salmonella sp. isolates from the United Kingdom and 1 Escherichia coli isolate from Greece was determined. Resistance (R) factors from Salmonella sp. isolates were designated R1818 and R7268 (R7268 encoding the current TEM-1). The E. coli isolate and its plasmid were named TEM (encoding the current TEM-2) because the isolate was recovered from a feces culture of an Athenian patient named Temoniera in 1963.

β-lactam resistance is a problem worldwide; >2,000 β-lactamases are currently identified. Of these β-lactamases, >200 enzymes are classified within TEM family, including extended-spectrum β-lactamases (ESBLs). However, the original TEM-1 and TEM-2 hydrolyze only penicillin derivatives.

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References

  1. Ambler  RP, Scott  GK. Partial amino acid sequence of penicillinase coded by Escherichia coli plasmid R6K. Proc Natl Acad Sci U S A. 1978;75:37326. DOIPubMed
  2. Anderson  ES, Datta  N. Resistance to penicillins and its transfer in Enterobacteriaceae. Lancet. 1965;1:4079. DOIPubMed
  3. Bonomo  RA. β-lactamases: a focus on current challenges. Cold Spring Harb Perspect Med. 2017;7:a025239. DOIPubMed
  4. Bush  K, Jacoby  GA, Medeiros  AA. A functional classification scheme for beta-lactamases and its correlation with molecular structure. Antimicrob Agents Chemother. 1995;39:121133. DOIPubMed
  5. Datta  N, Kontomichalou  P. Penicillinase synthesis controlled by infectious R factors in Enterobacteriaceae. Nature. 1965;208:23941. DOIPubMed
  6. Kontomichalou  P. Studies on resistance transfer factors. Pathol Microbiol (Basel). 1967;30:7193.PubMed
  7. Medeiros  AA. β-lactamases. Br Med Bull. 1984;40:1827. DOIPubMed
  8. Sutcliffe  JG. Nucleotide sequence of the ampicillin resistance gene of Escherichia coli plasmid pBR322. Proc Natl Acad Sci U S A. 1978;75:373741. DOIPubMed

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Cite This Article

DOI: 10.3201/eid2404.et2404

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Table of Contents – Volume 24, Number 4—April 2018

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Page created: March 19, 2018
Page updated: March 19, 2018
Page reviewed: March 19, 2018
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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