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Volume 24, Number 8—August 2018

Distinguishing Zika and Dengue Viruses through Simple Clinical Assessment, Singapore

Gabriel Yan1, Long Pang1, Alex R. Cook2, Hanley J. Ho2, Mar Soe Win, Ai Leng Khoo, Joshua G.X. Wong, Chun Kiat Lee, Benedict Yan, Roland Jureen, Siew Seen Ho, David C. Lye, Paul A. Tambyah, Yee Sin Leo, Dale Fisher, Jolene Oon, Natasha Bagdasarian, Angela Chow3, Nares Smitasin3, and Louis Yi Ann Chai3Comments to Author 
Author affiliations: National University Health System, Singapore (G. Yan, L. Pang, A.R. Cook, M.S. Win, S.S. Ho, P.A. Tambyah, D. Fisher, J. Oon, N. Bagdasarian, N. Smitasin, L.Y.A. Chai); National University of Singapore (L. Pang, A.R. Cook, P.A. Tambyah, D. Fisher, N. Bagdasarian, L.Y.A. Chai); Tan Tock Seng Hospital, Singapore (H.J. Ho, J.G.X. Wong, D.C. Lye, Y.S. Leo, A. Chow); National University Cancer Institute, Singapore (M.S. Win, L.Y.A. Chai); National Healthcare Group, Singapore (A.L. Khoo); National University Hospital, Singapore (C.K. Lee, B. Yan, R. Jureen)

Main Article

Table 2

Sensitivity and specificity using CDC and WHO definitions of suspected Zika virus infection in study of clinical assessments to distinguish Zika and dengue virus infections, Singapore*

Case definition
Source Criteria Patient meets criteria Zika virus positive, n = 34 Zika virus negative, n = 57 Total, 
n = 91 Sensitivity, % Specificity, %
Clinically compatible illness with >1 of the following not explained by another etiology: fever, rash, arthralgia, or conjunctivitis†

WHO Fever and/or rash and any of the following: arthralgia, arthritis, nonpurulent conjunctivitis Yes 24 19 43 71 67
No 10 38 48

*CDC, Centers for Disease Control and Prevention; WHO, World Health Organization.
†We excluded 2 additional criteria, complications of pregnancy and neurologic manifestations, because they were not present in our study population.

Main Article

1These authors contributed equally to this article.

2These authors contributed equally to this article.

3These authors contributed equally to this article.

Page created: July 18, 2018
Page updated: July 18, 2018
Page reviewed: July 18, 2018
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