Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 24, Number 8—August 2018
Dispatch

Anncaliia algerae Microsporidial Myositis, New South Wales, Australia

Gaurav Sutrave, Adam Maundrell, Caitlin Keighley, Zoe Jennings, Susan Brammah, Min-Xia Wang, Roger Pamphlett, Cameron E. Webb, Damien Stark, Helen Englert, David Gottlieb, Ian Bilmon, and Matthew R. WattsComments to Author 
Author affiliations: Westmead Hospital, Westmead, New South Wales, Australia (G. Sutrave, A. Maundrell, C. Keighley, C.E. Webb, H. Englert, D. Gottlieb, I. Bilmon, M.R. Watts); University of Sydney, Sydney, New South Wales, Australia (G. Sutrave, M.-X. Wang, R. Pamphlett, C.E. Webb, D. Gottlieb, I. Bilmon, M.R. Watts); New South Wales Health Pathology Institute of Clinical Pathology and Medical Research, Westmead (Z. Jennings, C.E. Webb, M.R. Watts); Concord Repatriation General Hospital, Concord West, New South Wales, Australia (S. Brammah); St. Vincent’s Hospital, Darlinghurst, New South Wales, Australia (D. Stark)

Main Article

Table 2

Serologic and laboratory test results for 7 case-patients with Anncaliia algerae microsporidial myositis from North America and New South Wales, Australia, 2004*

Test
 Abnormal result
 No. cases
Serum creatine kinase Elevated 7
Cardiac troponin Elevated 2
Erythrocyte sedimentation rate and C-reactive protein Elevated 5
Full blood count Lymphocytopenia 6
Serum albumin Decreased 5
Alanine aminotransferase and aspartate aminotransferase Elevated 5
Serum creatinine Elevated 2
Urinary protein Elevated 3
Nerve conduction studies, electromyography Myopathy, axonal neuropathy 6
Brain radiologic imaging Cerebral lesions 2
Cardiac magnetic resonance imaging Biventricular dysfunction 1
Small subunit rRNA gene PCR, muscle A. algerae DNA 7
Small subunit rRNA gene PCR, cerebrospinal fluid A. algerae DNA 1

*In 2 cases test results were only sourced from published reports (1,5) rather than patient records (2–4).

Main Article

References
  1. Coyle  CM, Weiss  LM, Rhodes  LV III, Cali  A, Takvorian  PM, Brown  DF, et al. Fatal myositis due to the microsporidian Brachiola algerae, a mosquito pathogen. N Engl J Med. 2004;351:42–7. DOIPubMedGoogle Scholar
  2. Watts  MR, Chan  RC, Cheong  EY, Brammah  S, Clezy  KR, Tong  C, et al. Anncaliia algerae microsporidial myositis. Emerg Infect Dis. 2014;20:185–91. DOIPubMedGoogle Scholar
  3. Field  AS, Paik  JY, Stark  D, Qiu  MR, Morey  A, Plit  ML, et al. Myositis due to the microsporidian Anncaliia (Brachiola) algerae in a lung transplant recipient. Transpl Infect Dis. 2012;14:169–76. DOIPubMedGoogle Scholar
  4. Chacko  B, Trevillian  P. Microsporidial myositis in a kidney transplant recipient [abstract 82]. Program and abstracts of Annual Scientific Meeting Transplantation Society of Australia and New Zealand. Canberra (ACT, Australia): Transplantation Society of Australia and New Zealand; 2013. p. 96.
  5. Boileau  M, Ferreira  J, Ahmad  I, Lavallée  C, Qvarnstrom  Y, Dufresne  SF. Successful treatment of disseminated Anncaliia algerae microsporidial infection with combination fumagillin and albendazole. Open Forum Infect Dis. 2016;3:ofw158. DOIPubMedGoogle Scholar
  6. Franzen  C, Nassonova  ES, Schölmerich  J, Issi  IV. Transfer of the members of the genus Brachiola (microsporidia) to the genus Anncaliia based on ultrastructural and molecular data. J Eukaryot Microbiol. 2006;53:26–35. DOIPubMedGoogle Scholar
  7. Santiana  M, Pau  C, Takvorian  PM, Cali  A. Analysis of the beta-tubulin gene and morphological changes of the microsporidium Anncaliia algerae both suggest albendazole sensitivity. J Eukaryot Microbiol. 2015;62:60–8. DOIPubMedGoogle Scholar
  8. Leitch  GJ, Scanlon  M, Shaw  A, Visvesvara  GS. Role of P glycoprotein in the course and treatment of Encephalitozoon microsporidiosis. Antimicrob Agents Chemother. 2001;45:73–8. DOIPubMedGoogle Scholar
  9. Vavra  J, Undeen  AH. Nosema algerae n. sp. (Cnidospora, Microsporida) a pathogen in a laboratory colony of Anopheles stephensi Liston (Diptera, Culicidae). J Protozool. 1970;17:240–9. DOIPubMedGoogle Scholar
  10. Trammer  T, Dombrowski  F, Doehring  M, Maier  WA, Seitz  HM. Opportunistic properties of Nosema algerae (Microspora), a mosquito parasite, in immunocompromised mice. J Eukaryot Microbiol. 1997;44:258–62. DOIPubMedGoogle Scholar
  11. Undeen  AH, Alger  NE. Nosema algerae: infection of the white mouse by a mosquito parasite. Exp Parasitol. 1976;40:86–8. DOIPubMedGoogle Scholar
  12. US Centers for Disease Control and Prevention. Rainwater collection [cited 2017 Nov 21]. https://www.cdc.gov/healthywater/drinking/private/rainwater-collection.html

Main Article

Page created: July 18, 2018
Page updated: July 18, 2018
Page reviewed: July 18, 2018
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external