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Volume 24, Number 8—August 2018
Research

Toxoplasmosis in Transplant Recipients, Europe, 2010–2014

Florence Robert-Gangneux1Comments to Author , Valeria Meroni1, Damien Dupont, Françoise Botterel, José M. Aguado Garcia2, Marie-Pierre Brenier-Pinchart, Isabelle Accoceberry, Hamdi Akan2, Isabella Abbate, Katia Boggian, Fabrizio Bruschi2, Jordi Carratalà2, Miruna David2, Lubos Drgona2, Olgica Djurković-Djaković, Maria Carmen Farinas, Francesca Genco, Effrossyni Gkrania-Klotsas2, Andreas H. Groll2, Edward Guy, Cédric Hirzel, Nina Khanna, Özgür Kurt1, Lia Monica Junie1, Tiziana Lazzarotto, Oscar Len2, Nicolas J. Mueller, Patricia Munoz2, Zoi Dorothea Pana2, Emmanuel Roilides2, Tijana Stajner, Christian van Delden, Isabelle Villena1, Hervé Pelloux1, and Oriol Manuel2
Author affiliations: Université Rennes, Rennes, France (F. Robert-Gangneux); Centre Hospitalier Universitaire de Rennes, Rennes (F. Robert-Gangneux); European Society of Clinical Microbiology and Infectious Diseases, Basel, Switzerland (V. Meroni, J.M. Aguado Garcia, F. Bruschi, J. Carratalà, M. David, L. Drgona, E. Gkrania-Klotsas, A.H. Groll, Ö. Kurt, L.M. Junie, O. Len, P. Munoz, Z.D. Pana, E. Roilides, I. Villena, H. Pelloux, O. Manuel); University of Pavia, Pavia, Italy (V. Meroni, F. Genco); Hôpital de la Croix-Rousse, Lyon, France (D. Dupont); Université Claude Bernard Lyon, Lyon (D. Dupont); Centre Hospitalier Universitaire Henri Mondor, Creteil, France (F. Botterel); University Hospital 12 de Octubre Universidad Complutense, Madrid, Spain (J.M. Aguado Garcia, H. Akan); Centre Hospitalier Universitaire Grenoble-Alpes, Grenoble, France (M.-P. Brenier-Pinchart); Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France (I. Accoceberry); Ankara University Cebeci Hospital, Ankara, Turkey (H. Akan); Lazzaro Spallanzani National Institute for Infectious Diseases, Rome, Italy (I. Abbate); St. Gallen Cantonal Hospital, St. Gallen, Switzerland (K. Boggian); Pisa University, Pisa, Italy (F. Bruschi); Bellvitge University Hospital-IDIBELL University of Barcelona, Barcelona, Spain (J. Carratalà); Queen Elizabeth Hospital, Birmingham, UK (M. David); Comenius University, Bratislava, Slovakia (L. Drgona); National Cancer Institute, Bratislava (L. Drgona); University of Belgrade, Belgrade, Serbia (O. Djurković-Djaković, T. Stajner); Hospital Universitario Marques de Valdecilla, Santander, Spain (M.C. Farinas); University of Cantabria, Santander (M.C. Farinas); Addenbrooke’s Hospital, Cambridge, UK (E. Gkrania-Klotsas); University Children’s Hospital Münster, Münster, Germany (A.H. Groll); Singleton Hospital, Swansea, Wales, UK (E. Guy); Bern University Hospital, Bern, Switzerland (C. Hirzel); University of Bern, Bern (C. Hirzel); Universitätsspital, Basel (N. Khanna); Acibadem Mehmet Ali Aydinlar, Istanbul, Turkey (Ö. Kurt); University of Medicine and Pharmacy Iuliu Hatieganu, Cluj Napoca, Romania (L.M. Junie); St. Orsola-Malpighi General Hospital, Bologna, Italy (T. Lazzarotto); University of Bologna, Bologna (T. Lazzarotto); Hospital Universitari Vall d’Hebron, Barcelona (O. Len); Zurich University Hospital, Zurich, Switzerland (N.J. Mueller); University of Zurich, Zurich (N.J. Mueller); Hospital General Gregorio Maranon, Madrid, Spain (P. Munoz); Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece (Z.D. Pana, E. Roilides); University Hospitals Geneva, Geneva, Switzerland (C. van Delden); Centre Hospitalier Universitaire de Reims, Reims, France (I. Villena); University Hospital, Lausanne, Switzerland (O. Manuel); University of Lausanne, Lausanne (O. Manuel)

Main Article

Table 1

Characteristics of 87 transplant patients with toxoplasmosis, according to clinical presentation, Europe, 2010–2014*

Variables
 Clinical type p value
Cerebral
 Ocular
 Disseminated
 Pulmonary
 Fever alone
 No signs
No. (%) patients
 13 (15)
 4 (5)
 19 (22)
 10 (11)
 10 (11)
 31 (36)
Patient age, y, mean ± SE
 37.0 ± 7.7
 60.7 ± 0.8
 47.8 ± 5.6
 53.1 ± 4.8
 35.5 ±4.4
 46.4 ± 4.2
 <0.0001
Time graft/diagnosis, wk, mean ± SE
 123 ± 151
 313 ± 175
 163 ± 124
 19 ± 11
 73 ± 43
 99 ± 51
 <0.05
Diagnosis by, no. (%)
PCR 13 (100) 3 (75) 17 (89) 9 (90) 9 (90) 26 (84) <0.001
Serology 3 (23) 3 (75) 9 (47) 2 (20) 5 (50) 5 (16) 0.2278
Imaging 12 (92) 3 (75) 8 (42) 7 (70) 0 2 (6) <0.01
Microscopy
 1 (8)
 0
 6 (32)
 1 (10)
 0
 0
 <0.01
Graft type, no. (%) <0.05
Liver, n = 8 1 (8) 1 (25) 3 (16) 2 (20) 0 1 (3)
Kidney, n = 9 1 (8) 1 (25) 1 (5) 2 (20) 3 (30) 1 (3)†
Heart, n = 12 0 1 (25) 5 (26) 0 2 (20) 4 (13)‡
Allo-HSC, n = 58
 11 (85)
 1 (25)
 10 (53)
 6 (60)
 5 (50)
 25 (81)§
No. with mismatch, n = 11
 0
 1 (25)
 5 (26)
 1 (10)
 4 (40)
 0
 <0.05
Survival, no. (%)
2 mo 5 (38) 4 (100) 13 (68) 5 (50) 10 (100) 24 (77) <0.0001
6 mo 2 (15) 4 (100) 10 (53) 5 (50) 7 (70) 18 (58) <0.001

*HSC, hematopoietic stem cell.
†This patient was receiving chemoprophylaxis.
‡1 patient was receiving chemoprophylaxis.
§11 patients were receiving chemoprophylaxis.

Main Article

1These authors are members of the Study Group for Clinical Parasitology of the European Society of Clinical Microbiology and Infectious Diseases.

2These authors are members of the Study Group for Infections in Compromised Hosts of the European Society of Clinical Microbiology and Infectious Diseases.

Page created: July 18, 2018
Page updated: July 18, 2018
Page reviewed: July 18, 2018
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