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Volume 24, Number 8—August 2018
Research

Toxoplasmosis in Transplant Recipients, Europe, 2010–2014

Florence Robert-Gangneux1Comments to Author , Valeria Meroni1, Damien Dupont, Françoise Botterel, José M. Aguado Garcia2, Marie-Pierre Brenier-Pinchart, Isabelle Accoceberry, Hamdi Akan2, Isabella Abbate, Katia Boggian, Fabrizio Bruschi2, Jordi Carratalà2, Miruna David2, Lubos Drgona2, Olgica Djurković-Djaković, Maria Carmen Farinas, Francesca Genco, Effrossyni Gkrania-Klotsas2, Andreas H. Groll2, Edward Guy, Cédric Hirzel, Nina Khanna, Özgür Kurt1, Lia Monica Junie1, Tiziana Lazzarotto, Oscar Len2, Nicolas J. Mueller, Patricia Munoz2, Zoi Dorothea Pana2, Emmanuel Roilides2, Tijana Stajner, Christian van Delden, Isabelle Villena1, Hervé Pelloux1, and Oriol Manuel2
Author affiliations: Université Rennes, Rennes, France (F. Robert-Gangneux); Centre Hospitalier Universitaire de Rennes, Rennes (F. Robert-Gangneux); European Society of Clinical Microbiology and Infectious Diseases, Basel, Switzerland (V. Meroni, J.M. Aguado Garcia, F. Bruschi, J. Carratalà, M. David, L. Drgona, E. Gkrania-Klotsas, A.H. Groll, Ö. Kurt, L.M. Junie, O. Len, P. Munoz, Z.D. Pana, E. Roilides, I. Villena, H. Pelloux, O. Manuel); University of Pavia, Pavia, Italy (V. Meroni, F. Genco); Hôpital de la Croix-Rousse, Lyon, France (D. Dupont); Université Claude Bernard Lyon, Lyon (D. Dupont); Centre Hospitalier Universitaire Henri Mondor, Creteil, France (F. Botterel); University Hospital 12 de Octubre Universidad Complutense, Madrid, Spain (J.M. Aguado Garcia, H. Akan); Centre Hospitalier Universitaire Grenoble-Alpes, Grenoble, France (M.-P. Brenier-Pinchart); Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France (I. Accoceberry); Ankara University Cebeci Hospital, Ankara, Turkey (H. Akan); Lazzaro Spallanzani National Institute for Infectious Diseases, Rome, Italy (I. Abbate); St. Gallen Cantonal Hospital, St. Gallen, Switzerland (K. Boggian); Pisa University, Pisa, Italy (F. Bruschi); Bellvitge University Hospital-IDIBELL University of Barcelona, Barcelona, Spain (J. Carratalà); Queen Elizabeth Hospital, Birmingham, UK (M. David); Comenius University, Bratislava, Slovakia (L. Drgona); National Cancer Institute, Bratislava (L. Drgona); University of Belgrade, Belgrade, Serbia (O. Djurković-Djaković, T. Stajner); Hospital Universitario Marques de Valdecilla, Santander, Spain (M.C. Farinas); University of Cantabria, Santander (M.C. Farinas); Addenbrooke’s Hospital, Cambridge, UK (E. Gkrania-Klotsas); University Children’s Hospital Münster, Münster, Germany (A.H. Groll); Singleton Hospital, Swansea, Wales, UK (E. Guy); Bern University Hospital, Bern, Switzerland (C. Hirzel); University of Bern, Bern (C. Hirzel); Universitätsspital, Basel (N. Khanna); Acibadem Mehmet Ali Aydinlar, Istanbul, Turkey (Ö. Kurt); University of Medicine and Pharmacy Iuliu Hatieganu, Cluj Napoca, Romania (L.M. Junie); St. Orsola-Malpighi General Hospital, Bologna, Italy (T. Lazzarotto); University of Bologna, Bologna (T. Lazzarotto); Hospital Universitari Vall d’Hebron, Barcelona (O. Len); Zurich University Hospital, Zurich, Switzerland (N.J. Mueller); University of Zurich, Zurich (N.J. Mueller); Hospital General Gregorio Maranon, Madrid, Spain (P. Munoz); Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece (Z.D. Pana, E. Roilides); University Hospitals Geneva, Geneva, Switzerland (C. van Delden); Centre Hospitalier Universitaire de Reims, Reims, France (I. Villena); University Hospital, Lausanne, Switzerland (O. Manuel); University of Lausanne, Lausanne (O. Manuel)

Main Article

Table 4

Characteristics of transplant patients with toxoplasmosis, according to graft type and comparison to overall graft population, Europe, 2010–2014*

Characteristics
Allo-HSC

Kidney

Liver

Heart
p value
Case-patients
All TP
Case-patients
All TP
Case-patients
All TP
Case-patients
All TP
Patients, no. 58 4,108 9 6,507 8 2,983 12 998 NA
Age, y, mean ± SE 46.8 ± 5.3 50.7 44.6 ± 5.9 50.9 55.1 ± 1.5 51.6 44.4 ± 6.4 47.5 NA
Female sex, %
43
38

44
63

38
30

17
22
NA
Male sex, %
57
62

56
37

62
70

83
78
NA
Mean time diagnosis/graft, wk, mean ± SE 20.6 ± 4.6 NA 198 ± 68 ND 152 ± 144 ND 441 ± 155 ND <0.0001
Mean time diagnosis/death, d, mean ± SE
47 ± 18
NA

33
ND

38 ± 17
ND

NA
ND
0.8595
Mismatched serologic results (D+/R–), no. (%)
0
NA

4 (33)
NA

3 (38)
NA

4 (33)
NA
0.8923
2-mo survival, no. (%) 36 (62) ND 8 (89) ND 5 (63) ND 12 (100) ND <0.05
  Deep site involvement 12 (43) ND 3 (60) ND 4 (57) ND 6 (100) ND 0.0513
  Fever only 5 (100) ND 3 (100) ND 0 ND 2 (100) ND 1
  No clinical signs
18 (72)


1 (100)


1 (100)


4 (100)

0.1407
6-mo survival, %† 38 84‡ 89 72 50 75§ 100 60 <0.0001
Deep site involvement 25 NA 60 NA 28 NA 100 NA <0.01
Fever only 40 NA 100 NA 0 NA 100 NA 0.2083

*D+, donor positive; NA, not applicable; ND, not determined; NS, not significant; R–, recipient negative; TP, transplant patients.
†The survival rate for the general TP population was calculated at time similar to the mean time of diagnosis of toxoplasmosis after graft in case-patients.
‡p<0.01 compared with case-patients.
§p<0.05 compared with case-patients.

Main Article

1These authors are members of the Study Group for Clinical Parasitology of the European Society of Clinical Microbiology and Infectious Diseases.

2These authors are members of the Study Group for Infections in Compromised Hosts of the European Society of Clinical Microbiology and Infectious Diseases.

Page created: July 18, 2018
Page updated: July 18, 2018
Page reviewed: July 18, 2018
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