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Volume 24, Number 9—September 2018
Online Report

World Health Organization Methodology to Prioritize Emerging Infectious Diseases in Need of Research and Development

Massinissa Si MehandComments to Author , Piers Millett, Farah Al-Shorbaji, Cathy Roth, Marie Paule Kieny, and Bernadette Murgue
Author affiliations: World Health Organization, Geneva, Switzerland (M. Si Mehand, P. Millett, F. Al-Shorbaji, M.P. Kieny, B. Murgue); Department for International Development, London, UK (C. Roth)

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Figure 3

Multicriteria scores of diseases considered in the 2017 prioritization exercise for the development of the World Health Organization R&D Blueprint to prioritize emerging infectious diseases in need of research and development. A) Disease final ranking using the geometric average of the comparison matrices. B) Disease final ranking using the arithmetic average of the raw data. Error bars correspond to SD, indicating disagreement among experts. C) Disease final ranking using the SMART Vaccines

Figure 3. Multicriteria scores of diseases considered in the 2017 prioritization exercise for the development of the World Health Organization R&D Blueprint to prioritize emerging infectious diseases in need of research and development. A) Disease final ranking using the geometric average of the comparison matrices. B) Disease final ranking using the arithmetic average of the raw data. Error bars correspond to SD, indicating disagreement among experts. C) Disease final ranking using the SMART Vaccines prioritization tool (56). P1, Ebola virus infection; P2, Marburg virus infection; P3, Middle East Respiratory Syndrome coronavirus infection; P4, severe acute respiratory syndrome; P5, Lassa virus infection; P6, Nipah virus infection; P7, Rift Valley fever; P8, Zika virus infection; P9, Crimean-Congo hemorrhagic fever; P10, severe fever with thrombocytopenia syndrome; P11, South American hemorrhagic fever; P12, plague; P13, hantavirus infection.

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References
  1. Word Health Organization. Sixty-ninth World Health Assembly resolution WHA69.23: follow-up of the report of the Consultative Expert Working Group on Research and Development: financing and coordination [cited 2016 May 28]. http://apps.who.int/gb/ebwha/pdf_files/WHA69/A69_R23-en.pdf
  2. Word Health Organization. An R and D blueprint for action to prevent epidemics—plan of action [cited 2016 May 30]. http://www.who.int/blueprint/about/r_d_blueprint_plan_of_action.pdf?ua=1
  3. Word Health Organization. Methodology for prioritizing severe emerging diseases for research and development [cited 2017 Feb 19]. http://www.who.int/blueprint/priority-diseases/RDBlueprint-PrioritizationTool.pdf?ua=1
  4. World Health Organization. The 2015 WHO R and D Blueprint priority diseases [cited 2015 Dec 10]. http://www.who.int/medicines/ebola-treatment/WHO-list-of-top-emerging-diseases/en/
  5. European Centre for Disease Prevention and Control. Best practices in ranking emerging infectious disease threats: a literature review [cited 2015 Feb 1]. https://ecdc.europa.eu/sites/portal/files/media/en/publications/Publications/emerging-infectious-disease-threats-best-practices-ranking.pdf
  6. Rist  CL, Arriola  CS, Rubin  C. Prioritizing zoonoses: a proposed one health tool for collaborative decision-making. PLoS One. 2014;9:e109986. DOIPubMedGoogle Scholar
  7. Brookes  VJ, Del Rio Vilas  VJ, Ward  MP. Disease prioritization: what is the state of the art? Epidemiol Infect. 2015;143:291122. DOIPubMedGoogle Scholar
  8. Kadohira  M, Hill  G, Yoshizaki  R, Ota  S, Yoshikawa  Y. Stakeholder prioritization of zoonoses in Japan with analytic hierarchy process method. Epidemiol Infect. 2015;143:147785. DOIPubMedGoogle Scholar
  9. Munyua  P, Bitek  A, Osoro  E, Pieracci  EG, Muema  J, Mwatondo  A, et al. Prioritization of zoonotic diseases in Kenya, 2015. PLoS One. 2016;11:e0161576. DOIPubMedGoogle Scholar
  10. Garner  MJ, Carson  C, Lingohr  EJ, Fazil  A, Edge  VL, Trumble Waddell  J. An assessment of antimicrobial resistant disease threats in Canada. PLoS One. 2015;10:e0125155. DOIPubMedGoogle Scholar
  11. Ng  V, Sargeant  JM. A quantitative and novel approach to the prioritization of zoonotic diseases in North America: a public perspective. PLoS One. 2012;7:e48519. DOIPubMedGoogle Scholar
  12. Ng  V, Sargeant  JM. A stakeholder-informed approach to the identification of criteria for the prioritization of zoonoses in Canada. PLoS One. 2012;7:e29752. DOIPubMedGoogle Scholar
  13. Ng  V, Sargeant  JM. A quantitative approach to the prioritization of zoonotic diseases in North America: a health professionals’ perspective. PLoS One. 2013;8:e72172. DOIPubMedGoogle Scholar
  14. Humblet  M-F, Vandeputte  S, Albert  A, Gosset  C, Kirschvink  N, Haubruge  E, et al. Multidisciplinary and evidence-based method for prioritizing diseases of food-producing animals and zoonoses. Emerg Infect Dis. 2012;18:e1. DOIPubMedGoogle Scholar
  15. Wilson  S-J, Ward  MP, Garner  MG. A framework for assessing the intangible impacts of emergency animal disease. Prev Vet Med. 2013;111:1949. DOIPubMedGoogle Scholar
  16. Ng  V, Sargeant  J. Prioritizing zoonotic diseases: differences in perspectives between human and animal health professionals in North America. Zoonoses Public Health. 2015.PubMedGoogle Scholar
  17. Giesecke  J. Choosing diseases for surveillance. Lancet. 1999;353:344. DOIPubMedGoogle Scholar
  18. Carter  A; National Advisory Committee on Epidemiology Subcommittee*. Establishing goals, techniques and priorities for national communicable disease surveillance. Can J Infect Dis. 1991;2:3740. DOIPubMedGoogle Scholar
  19. Doherty  J-A. Establishing priorities for national communicable disease surveillance. Can J Infect Dis. 2000;11:214. DOIPubMedGoogle Scholar
  20. Brioudes  A, Warner  J, Hedlefs  R, Gummow  B. Diseases of livestock in the Pacific Islands region: setting priorities for food animal biosecurity. Acta Trop. 2015;143:6676. DOIPubMedGoogle Scholar
  21. Rushdy  A, O’Mahony  M. PHLS overview of communicable diseases 1997: results of a priority setting exercise. Commun Dis Rep CDR Suppl. 1998;8:S112.PubMedGoogle Scholar
  22. Horby  P, Rushdy  A, Graham  C, O’Mahony  M; PHLS Overview of Communicable Diseases Committee. PHLS overview of communicable diseases 1999. Commun Dis Public Health. 2001;4:817.PubMedGoogle Scholar
  23. Lapid  R, King  R, Yakobson  B, Shalom  U, Moran-Gilad  J. Wildlife Pathogen Surveillance in Israel to Inform Human and Animal Infectious Disease Control: a Prioritization Exercise. Isr J Vet Med. 2016;71:3341.
  24. McKenzie  J, Simpson  H, Langstaff  I. Development of methodology to prioritise wildlife pathogens for surveillance. Prev Vet Med. 2007;81:194210. DOIPubMedGoogle Scholar
  25. Maino  M, Pérez  P, Oviedo  P, Sotomayor  G, Abalos  P. The analytic hierarchy process in decisionmaking for caprine health programmes. Rev Sci Tech. 2012;31:88997. DOIPubMedGoogle Scholar
  26. Havelaar  AH, van Rosse  F, Bucura  C, Toetenel  MA, Haagsma  JA, Kurowicka  D, et al. Prioritizing emerging zoonoses in the Netherlands. PLoS One. 2010;5:e13965. DOIPubMedGoogle Scholar
  27. Kurowicka  D, Bucura  C, Cooke  R, Havelaar  A. Probabilistic inversion in priority setting of emerging zoonoses. Risk Anal. 2010;30:71523. DOIPubMedGoogle Scholar
  28. Cox  R, Sanchez  J, Revie  CW. Multi-criteria decision analysis tools for prioritising emerging or re-emerging infectious diseases associated with climate change in Canada. PLoS One. 2013;8:e68338. DOIPubMedGoogle Scholar
  29. Hongoh  V, Michel  P, Gosselin  P, Samoura  K, Ravel  A, Campagna  C, et al. Multi-stakeholder decision aid for improved prioritization of the public health impact of climate sensitive infectious diseases. Int J Environ Res Public Health. 2016;13:419. DOIPubMedGoogle Scholar
  30. Stebler  N, Schuepbach-Regula  G, Braam  P, Falzon  LC. Use of a modified Delphi panel to identify and weight criteria for prioritization of zoonotic diseases in Switzerland. Prev Vet Med. 2015;121:1659. DOIPubMedGoogle Scholar
  31. Stebler  N, Schuepbach-Regula  G, Braam  P, Falzon  LC. Weighting of criteria for disease prioritization using conjoint analysis and based on health professional and student opinion. PLoS One. 2016;11:e0151394. DOIPubMedGoogle Scholar
  32. Brookes  VJ, Hernández-Jover  M, Cowled  B, Holyoake  PK, Ward  MP. Building a picture: Prioritisation of exotic diseases for the pig industry in Australia using multi-criteria decision analysis. Prev Vet Med. 2014;113:10317. DOIPubMedGoogle Scholar
  33. Del Rio Vilas  VJ, Voller  F, Montibeller  G, Franco  LA, Sribhashyam  S, Watson  E, et al. An integrated process and management tools for ranking multiple emerging threats to animal health. Prev Vet Med. 2013;108:94102. DOIPubMedGoogle Scholar
  34. Ruzante  JM, Davidson  VJ, Caswell  J, Fazil  A, Cranfield  JA, Henson  SJ, et al. A multifactorial risk prioritization framework for foodborne pathogens. Risk Anal. 2010;30:72442. DOIPubMedGoogle Scholar
  35. Dahl  V, Tegnell  A, Wallensten  A. Communicable diseases prioritized according to their public health relevance, Sweden, 2013. PLoS One. 2015;10:e0136353. DOIPubMedGoogle Scholar
  36. Cardoen  S, Van Huffel  X, Berkvens  D, Quoilin  S, Ducoffre  G, Saegerman  C, et al. Evidence-based semiquantitative methodology for prioritization of foodborne zoonoses. Foodborne Pathog Dis. 2009;6:108396. DOIPubMedGoogle Scholar
  37. Bouwknegt  M, Havelaar  A, Neslo  R, de Roda Husman  AM, Hogerwerf  L, van Steenbergen  J, et al. Ranking infectious disease risks to support preparedness prioritization in the European Union. Eur J Public Health. 2015;25(Suppl 3):ckv167.036-ckv167.036.
  38. Balabanova  Y, Gilsdorf  A, Buda  S, Burger  R, Eckmanns  T, Gärtner  B, et al. Communicable diseases prioritized for surveillance and epidemiological research: results of a standardized prioritization procedure in Germany, 2011. PLoS One. 2011;6:e25691. DOIPubMedGoogle Scholar
  39. Gilsdorf  A, Krause  G. Prioritisation of infectious diseases in public health: feedback on the prioritisation methodology, 15 July 2008 to 15 January 2009. Euro Surveill. 2011;16:19861.PubMedGoogle Scholar
  40. Krause  G; Working Group on Prioritization at Robert Koch Institute. How can infectious diseases be prioritized in public health? A standardized prioritization scheme for discussion. EMBO Rep. 2008;9(Suppl 1):S227. DOIPubMedGoogle Scholar
  41. Ciliberti  A, Gavier-Widén  D, Yon  L, Hutchings  MR, Artois  M. Prioritisation of wildlife pathogens to be targeted in European surveillance programmes: Expert-based risk analysis focus on ruminants. Prev Vet Med. 2015;118:27184. DOIPubMedGoogle Scholar
  42. McIntyre  KM, Setzkorn  C, Hepworth  PJ, Morand  S, Morse  AP, Baylis  M. A quantitative prioritisation of human and domestic animal pathogens in Europe. PLoS One. 2014;9:e103529. DOIPubMedGoogle Scholar
  43. Cox  R, McIntyre  KM, Sanchez  J, Setzkorn  C, Baylis  M, Revie  CW. Comparison of the H‐index scores among pathogens identified as emerging hazards in North America. Transbound Emerg Dis. 2016;63:7991. DOIPubMedGoogle Scholar
  44. Remme  JHF, Blas  E, Chitsulo  L, Desjeux  PMP, Engers  HD, Kanyok  TP, et al. Strategic emphases for tropical diseases research: a TDR perspective. Trends Parasitol. 2002;18:4216. DOIPubMedGoogle Scholar
  45. World Health Organization. The Dubrovnik pledge on surveillance and prioritization of infectious diseases [cited 2002 Nov 23]. http://www.euro.who.int/__data/assets/pdf_file/0005/128039/E78888.pdf
  46. Cox  R, Revie  CW, Sanchez  J. The use of expert opinion to assess the risk of emergence or re-emergence of infectious diseases in Canada associated with climate change. PLoS One. 2012;7:e41590. DOIPubMedGoogle Scholar
  47. Morgan  D, Kirkbride  H, Hewitt  K, Said  B, Walsh  AL. Assessing the risk from emerging infections. Epidemiol Infect. 2009;137:152130. DOIPubMedGoogle Scholar
  48. Palmer  S, Brown  D, Morgan  D. Early qualitative risk assessment of the emerging zoonotic potential of animal diseases. BMJ. 2005;331:125660. DOIPubMedGoogle Scholar
  49. World Health Organization. R&D Blueprint: progress in prioritizing diseases with epidemic potential [cited 2016 Nov 18]. http://www.who.int/blueprint/what/research-development/prioritizing_diseases_progress/en
  50. World Health Organization. The 2017 annual review of diseases prioritized under the Research and Development Blueprint informal consultation 24–25 January 2017, Geneva, Switzerland [cited 2017 Mar 30]. http://www.who.int/blueprint/what/research-development/2017-Prioritization-Long-Report.pdf?ua=1
  51. Toloie-Eshlaghy  A, Nazari Farokhi  E. Measuring the importance and the weight of decision makers in the criteria weighting activities of group decision making process. American Journal of Scientific Research. 2011;24:612.
  52. Sutherland  WJ, Broad  S, Caine  J, Clout  M, Dicks  LV, Doran  H, et al. A horizon scan of global conservation issues for 2016. Trends Ecol Evol. 2016;31:4453. DOIPubMedGoogle Scholar
  53. Saaty  TL. How to make a decision: the analytic hierarchy process. Eur J Oper Res. 1990;48:926. DOIGoogle Scholar
  54. Saaty  TL. Decision making with the analytic hierarchy process. Int J Serv Sci. 2008;1:8398. DOIGoogle Scholar
  55. Saito  EK, Shea  S, Jones  A, Ramos  G, Pitesky  M. A cooperative approach to animal disease response activities: Analytical hierarchy process (AHP) and vvIBD in California poultry. Prev Vet Med. 2015;121:12331. DOIPubMedGoogle Scholar
  56. Madhavan  G, Phelps  C, Sangha  K, Levin  S, Rappuoli  R. Bridging the gap: need for a data repository to support vaccine prioritization efforts. Vaccine. 2015;33(Suppl 2):B349. DOIPubMedGoogle Scholar
  57. Pannucci  CJ, Wilkins  EG. Identifying and avoiding bias in research. Plast Reconstr Surg. 2010;126:61925. DOIPubMedGoogle Scholar
  58. Brookes  VJ, Hernández-Jover  M, Neslo  R, Cowled  B, Holyoake  P, Ward  MP. Identifying and measuring stakeholder preferences for disease prioritisation: A case study of the pig industry in Australia. Prev Vet Med. 2014;113:11831. DOIPubMedGoogle Scholar
  59. McCormick  TH, Zheng  T. Adjusting for recall bias in “How many X’s do you know?” surveys [cited 2017 Apr 10]. http://www.stat.columbia.edu/~tzheng/files/McCormick_jsm07.pdf
  60. World Health Organization. The R&D Blueprint—accelerating R&D processes [cited 2018 Apr 5]. http://www.who.int/blueprint/what/research-development/en
  61. World Health Organization. The R&D Blueprint—developing new norms and standards tailored to the epidemic context [cited 2018 Apr 5]. http://www.who.int/blueprint/what/norms-standards/en

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