Volume 24, Number 9—September 2018
Synopsis
Systematic Review and Meta-analysis of Postexposure Prophylaxis for Crimean-Congo Hemorrhagic Fever Virus among Healthcare Workers
Table
Country (references) | No. (%) |
|||||
---|---|---|---|---|---|---|
Exposed, N = 175 | High risk, n = 107 | Moderate risk, n = 65 | Low or no known risk, n = 3 | Infected, n = 102 | Died, n = 34 | |
Turkey (5,7,20–25) | 49 (28) | 23 (22) | 26 (40) | 0 | 19 (19) | 3 (9) |
Pakistan (15,26–32) | 45 (26) | 21 (20) | 24 (36) | 0 | 18 (18) | 6 (18) |
Germany (6) | 18 (10) | 18 (17) | 0 | 0 | 2 (2) | 0 |
Iran (33–36) | 12 (7) | 10 (9) | 1 (2) | 1 (33) | 12 (12) | 3 (9) |
India (18,19) | 8 (5) | 5 (5) | 3 (5) | 0 | 8 (8) | 6 (18) |
Russia (8) | 8 (5) | 6 (6) | 0 | 2 (67) | 8 (8) | 0 |
South Africa (9) | 8 (5) | 3 (3) | 5 (8) | 0 | 8 (8) | 2 (6) |
Tajikistan (37) | 7 (4) | 7 (7) | 0 | 0 | 7 (7) | 2 (6) |
United Arab Emirates (38) | 5 (3) | 1 (1) | 4 (6) | 0 | 5 (5) | 2 (6) |
Kazakhstan (40) | 5 (3) | 3 (3) | 2 (3) | 0 | 5 (5) | 3 (9) |
Mauritania (39) | 5 (3) | 5 (5) | 0 | 0 | 5 (5) | 5 (15) |
Sudan (41,42) | 3 (2) | 2 (2) | 1 (2) | 0 | 3 (3) | 2 (6) |
Albania (12) | 1 (1) | 1 (1) | 0 | 0 | 1 (1) | 0 |
Spain (2) | 1 (1) | (1) | 0 | 0 | 1 (1) | 0 |
References
- Ergönül O. Crimean-Congo haemorrhagic fever. Lancet Infect Dis. 2006;6:203–14. DOIPubMedGoogle Scholar
- Negredo A, de la Calle-Prieto F, Palencia-Herrejón E, Mora-Rillo M, Astray-Mochales J, Sánchez-Seco MP, et al.; Crimean Congo Hemorrhagic Fever@Madrid Working Group. Autochthonous Crimean-Congo hemorrhagic fever in Spain. N Engl J Med. 2017;377:154–61. DOIPubMedGoogle Scholar
- Tarantola A, Ergonul O, Tattevin P. Estimates and prevention of Crimean-Congo hemorrhagic fever risks for health-care workers. In: Ergonul O, Whitehouse CA, editors. Crimean-Congo hemorrhagic fever: a global perspective. Dordrecht (the Netherlands): Springer; 2007. p. 281–94.
- Bausch DG, Hadi CM, Khan SH, Lertora JJ. Review of the literature and proposed guidelines for the use of oral ribavirin as postexposure prophylaxis for Lassa fever. Clin Infect Dis. 2010;51:1435–41. DOIPubMedGoogle Scholar
- Celikbas AK, Dokuzoğuz B, Baykam N, Gok SE, Eroğlu MN, Midilli K, et al. Crimean-Congo hemorrhagic fever among health care workers, Turkey. Emerg Infect Dis. 2014;20:477–9. DOIPubMedGoogle Scholar
- Conger NG, Paolino KM, Osborn EC, Rusnak JM, Günther S, Pool J, et al. Health care response to CCHF in US soldier and nosocomial transmission to health care providers, Germany, 2009. Emerg Infect Dis. 2015;21:23–31. DOIPubMedGoogle Scholar
- Guner R, Hasanoglu I, Tasyaran MA, Yapar D, Keske S, Guven T, et al. Is ribavirin prophylaxis effective for nosocomial transmission of Crimean-Congo hemorrhagic fever? Vector Borne Zoonotic Dis. 2014;14:601–5. DOIPubMedGoogle Scholar
- Pshenichnaya NY, Nenadskaya SA. Probable Crimean-Congo hemorrhagic fever virus transmission occurred after aerosol-generating medical procedures in Russia: nosocomial cluster. Int J Infect Dis. 2015;33:120–2. DOIPubMedGoogle Scholar
- Richards GA. Nososcomial transmission of viral haemorrhagic fever in South Africa. S Afr Med J. 2015;105:709–12. DOIPubMedGoogle Scholar
- Leblebicioglu H, Sunbul M, Guner R, Bodur H, Bulut C, Duygu F, et al. Healthcare-associated Crimean-Congo haemorrhagic fever in Turkey, 2002-2014: a multicentre retrospective cross-sectional study. Clin Microbiol Infect. 2016;22:387.e1–4. DOIPubMedGoogle Scholar
- Papa A, Bino S, Llagami A, Brahimaj B, Papadimitriou E, Pavlidou V, et al. Crimean-Congo hemorrhagic fever in Albania, 2001. Eur J Clin Microbiol Infect Dis. 2002;21:603–6. DOIPubMedGoogle Scholar
- Harxhi A, Pilaca A, Delia Z, Pano K, Rezza G. Crimean-Congo hemorrhagic fever: a case of nosocomial transmission. Infection. 2005;33:295–6. DOIPubMedGoogle Scholar
- Fisher-Hoch SP, Khan JA, Rehman S, Mirza S, Khurshid M, McCormick JB. Crimean Congo-haemorrhagic fever treated with oral ribavirin. Lancet. 1995;346:472–5. DOIPubMedGoogle Scholar
- Altaf A, Luby S, Ahmed AJ, Zaidi N, Khan AJ, Mirza S, et al. Outbreak of Crimean-Congo haemorrhagic fever in Quetta, Pakistan: contact tracing and risk assessment. Trop Med Int Health. 1998;3:878–82. DOIPubMedGoogle Scholar
- Swanepoel R, Shepherd AJ, Leman PA, Shepherd SP, McGillivray GM, Erasmus MJ, et al. Epidemiologic and clinical features of Crimean-Congo hemorrhagic fever in southern Africa. Am J Trop Med Hyg. 1987;36:120–32. DOIPubMedGoogle Scholar
- van de Wal BW, Joubert JR, van Eeden PJ, King JB. A nosocomial outbreak of Crimean-Congo haemorrhagic fever at Tygerberg Hospital. Part IV. Preventive and prophylactic measures. S Afr Med J. 1985;68:729–32.PubMedGoogle Scholar
- Mishra AC, Mehta M, Mourya DT, Gandhi S. Crimean-Congo haemorrhagic fever in India. Lancet. 2011;378:372. DOIPubMedGoogle Scholar
- Patel AK, Patel KK, Mehta M, Parikh TM, Toshniwal H, Patel K. First Crimean-Congo hemorrhagic fever outbreak in India. J Assoc Physicians India. 2011;59:585–9.PubMedGoogle Scholar
- Stewart LA, Clarke M, Rovers M, Riley RD, Simmonds M, Stewart G, et al.; PRISMA-IPD Development Group. Preferred reporting items for systematic review and meta-analyses of individual participant data. The PRISMA-IPD statement. JAMA. 2015;313:1657–65. DOIPubMedGoogle Scholar
- Bulut C, Yilmaz GR, Karakoc E, Önde U, Kocak Tufan Z, Demiröz AP. Risk of Crimean-Congo haemorrhagic fever among healthcare workers. Presented at: 19th European Congress of Clinical Microbiology and Infectious Diseases; May 16–19, 2009; Helsinki, Finland.
- Guven G, Talan L, Altintas ND, Memikoglu KO, Yoruk F, Azap A. An unexpected fatal CCHF case and management of exposed health care workers. Int J Infect Dis. 2017;55:118–21. DOIPubMedGoogle Scholar
- Parlak E, Ertürk A, Koşan Z, Parlak M, Özkurt Z. A nosocomial outbreak of Crimean-Congo hemorrhagic fever. J Microbiol Infect Dis. 2015;5:5–9. DOIGoogle Scholar
- Yildirmak T, Tulek N, Bulut C. Crimean-Congo haemorrhagic fever: transmission to visitors and healthcare workers. Infection. 2016;44:687–9. DOIPubMedGoogle Scholar
- Tütüncü EE, Gurbuz Y, Ozturk B, Kuscu F, Sencan I. Crimean Congo haemorrhagic fever, precautions and ribavirin prophylaxis: a case report. Scand J Infect Dis. 2009;41:378–80. DOIPubMedGoogle Scholar
- Sunbul M, Esen S, Fletcher TE, Dilek A, Guler N, Beeching NJ, et al. A fatal case of healthcare associated Crimean-Congo haemorrhagic fever with severe disease and multi-organ failure. J Infect. 2016;72:253–5. DOIPubMedGoogle Scholar
- Burney MI, Ghafoor A, Saleen M, Webb PA, Casals J. Nosocomial outbreak of viral hemorrhagic fever caused by Crimean Hemorrhagic fever-Congo virus in Pakistan, January 1976. Am J Trop Med Hyg. 1980;29:941–7. DOIPubMedGoogle Scholar
- Bangash SA, Khan EA. Treatment and prophylaxis with ribavirin for Crimean-Congo Hemorrhagic Fever—is it effective? J Pak Med Assoc. 2003;53:39–41.PubMedGoogle Scholar
- Athar MN, Baqai HZ, Ahmad M, Khalid MA, Bashir N, Ahmad AM, et al. Short report: Crimean-Congo hemorrhagic fever outbreak in Rawalpindi, Pakistan, February 2002. Am J Trop Med Hyg. 2003;69:284–7.PubMedGoogle Scholar
- Hasan Z, Mahmood F, Jamil B, Atkinson B, Mohammed M, Samreen A, et al. Crimean-Congo hemorrhagic fever nosocomial infection in a immunosuppressed patient, Pakistan: case report and virological investigation. J Med Virol. 2013;85:501–4. DOIPubMedGoogle Scholar
- Yadav PD, Patil DY, Shete AM, Kokate P, Goyal P, Jadhav S, et al. Nosocomial infection of CCHF among health care workers in Rajasthan, India. BMC Infect Dis. 2016;16:624. DOIPubMedGoogle Scholar
- Yadav PD, Raut CG, Mourya DT. Re-occurrence of Crimean-Congo haemorrhagic fever in Ahmedabad, Gujarat, India (2012): a fatal case report. Indian J Med Res. 2013;138:1027–8.PubMedGoogle Scholar
- Jamil B, Hasan RS, Sarwari AR, Burton J, Hewson R, Clegg C. Crimean-Congo hemorrhagic fever: experience at a tertiary care hospital in Karachi, Pakistan. Trans R Soc Trop Med Hyg. 2005;99:577–84. DOIPubMedGoogle Scholar
- Naderi HR, Sarvghad MR, Bojdy A, Hadizadeh MR, Sadeghi R, Sheybani F. Nosocomial outbreak of Crimean-Congo haemorrhagic fever. Epidemiol Infect. 2011;139:862–6. DOIPubMedGoogle Scholar
- Naderi HR, Sheybani F, Bojdi A, Khosravi N, Mostafavi I. Fatal nosocomial spread of Crimean-Congo hemorrhagic fever with very short incubation period. Am J Trop Med Hyg. 2013;88:469–71. DOIPubMedGoogle Scholar
- Mardani M, Keshtkar-Jahromi M, Ataie B, Adibi P. Crimean-Congo hemorrhagic fever virus as a nosocomial pathogen in Iran. Am J Trop Med Hyg. 2009;81:675–8. DOIPubMedGoogle Scholar
- Chinikar S, Shayesteh M, Khakifirouz S, Jalali T, Rasi Varaie FS, Rafigh M, et al. Nosocomial infection of Crimean-Congo haemorrhagic fever in eastern Iran: case report. Travel Med Infect Dis. 2013;11:252–5. DOIPubMedGoogle Scholar
- Tishkova FH, Belobrova EA, Valikhodzhaeva M, Atkinson B, Hewson R, Mullojonova M. Crimean-Congo hemorrhagic fever in Tajikistan. Vector Borne Zoonotic Dis. 2012;12:722–6. DOIPubMedGoogle Scholar
- Suleiman MNEH, Muscat-Baron JM, Harries JR, Satti AGO, Platt GS, Bowen ETW, et al. Congo/Crimean haemorrhagic fever in Dubai. An outbreak at the Rashid Hospital. Lancet. 1980;2:939–41. DOIPubMedGoogle Scholar
- Nabeth P, Cheikh DO, Lo B, Faye O, Vall IO, Niang M, et al. Crimean-Congo hemorrhagic fever, Mauritania. Emerg Infect Dis. 2004;10:2143–9. DOIPubMedGoogle Scholar
- ProMED-RUS. Crimean-Congo hemorrhagic fever-Kazakhstan (South Kazakhstan). ProMed. 2009 Jul 15 [cited 2016 Feb 21]. http://www.promedmail.org/, archive no. 20090715.2529.
- Aradaib IE, Erickson BR, Mustafa ME, Khristova ML, Saeed NS, Elageb RM, et al. Nosocomial outbreak of Crimean-Congo hemorrhagic fever, Sudan. Emerg Infect Dis. 2010;16:837–9. DOIPubMedGoogle Scholar
- Elata AT, Karsany MS, Elageb RM, Hussain MA, Eltom KH, Elbashir MI, et al. A nosocomial transmission of crimean-congo hemorrhagic fever to an attending physician in North Kordufan, Sudan. Virol J. 2011;8:303. DOIPubMedGoogle Scholar
- Bente DA, Forrester NL, Watts DM, McAuley AJ, Whitehouse CA, Bray M. Crimean-Congo hemorrhagic fever: history, epidemiology, pathogenesis, clinical syndrome and genetic diversity. Antiviral Res. 2013;100:159–89. DOIPubMedGoogle Scholar
- Ince Y, Yasa C, Metin M, Sonmez M, Meram E, Benkli B, et al. Crimean-Congo hemorrhagic fever infections reported by ProMED. Int J Infect Dis. 2014;26:44–6. DOIPubMedGoogle Scholar
- Dokuzoguz B, Celikbas AK, Gök SE, Baykam N, Eroglu MN, Ergönül Ö. Severity scoring index for Crimean-Congo hemorrhagic fever and the impact of ribavirin and corticosteroids on fatality. Clin Infect Dis. 2013;57:1270–4. DOIPubMedGoogle Scholar
- Ergonul O. Treatment of Crimean-Congo hemorrhagic fever. Antiviral Res. 2008;78:125–31. DOIPubMedGoogle Scholar
- Ergonul O. DEBATE (see Elaldi N et al, Efficacy of oral ribavirin treatment in Crimean-Congo haemorrhagic fever: a quasi-experimental study from Turkey. Journal of Infection 2009; 58: 238-244): Biases and misinterpretation in the assessment of the efficacy of oral ribavirin in the treatment of Crimean-Congo hemorrhagic fever. J Infect. 2009;59:284–6, author reply 286–9. DOIPubMedGoogle Scholar
- Pourahmad M, Raoofi R, Chinikar S, Ghiasi SM, Ghalyanchi-Langeroudi A. Nosocomial transmission of Crimean-Congo hemorrhagic fever in a health care worker, Fars Province, Iran. Iran J Clin Infect Dis. 2011;6:47–50.
- Ergonul O, Zeller H, Celikbas A, Dokuzoguz B. The lack of Crimean-Congo hemorrhagic fever virus antibodies in healthcare workers in an endemic region. Int J Infect Dis. 2007;11:48–51. DOIPubMedGoogle Scholar
- Mardani M, Rahnavardi M, Rajaeinejad M, Naini KH, Chinikar S, Pourmalek F, et al. Crimean-Congo hemorrhagic fever among health care workers in Iran: a seroprevalence study in two endemic regions. Am J Trop Med Hyg. 2007;76:443–5.PubMedGoogle Scholar
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