Volume 25, Number 1—January 2019
Dispatch
Canine Influenza Virus A(H3N2) Clade with Antigenic Variation, China, 2016–2017
Yanli Lyu1, Shikai Song1, Liwei Zhou1, Guoxia Bing, Qian Wang, Haoran Sun, Mingyue Chen, Junyi Hu, Mingyang Wang, Honglei Sun, Juan Pu, Zhaofei Xia, Jinhua Liu, and Yipeng Sun
Table 1
Possible mammalian adaptation related to amino acid substitutions in CIV H3N2, China, 2016–2017*
| Category |
Virus protein, amino acid position, amino acid (frequency, %) |
||||
|---|---|---|---|---|---|
| Polymerase basic 2 | Hemagglutinin | ||||
| 251 |
590 |
146 |
242 |
||
| CIV H3N2, 2006–2015 | K (89.19), R† (8.11), G (2.70) | G (100) | G (91.89), S (8.11) | V (100) | |
| CIV H3N2, 2016–2017 | R† (100) | S† (100) | S (100) | I (100) | |
| Influenza virus A(H3N2) in humans | R† (99.82), K (0.14), G (0.04) | S† (89.76), G (10.06), N (0.14), T (0.04), R (0.01) | S (99.57), G (0.42), F (0.01) | I (99.29), V (0.39), M (0.20), T (0.08), L (0.03), K (0.02) | |
| Influenza A(H1N1)pdm09 virus | R† (98.99), K (0.99), I (0.02) | S† (99.43), N (0.35), G (0.22) | K (99.64), N (0.23), R (0.07), E (0.06) | F (99.99), L (0.01) | |
*CIV, canine influenza virus.
†Known determinant for adaptation to mammals.
1These authors contributed equally to this article.
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