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Volume 25, Number 1—January 2019
Dispatch

Meat and Fish as Sources of Extended-Spectrum β-Lactamase–Producing Escherichia coli, Cambodia

Maya NadimpalliComments to Author , Yith Vuthy, Agathe de Lauzanne, Laetitia Fabre, Alexis Criscuolo, Malika Gouali, Bich-Tram Huynh, Thierry Naas, Thong Phe, Laurence Borand, Jan Jacobs, Alexandra Kerléguer, Patrice Piola, Didier Guillemot, Simon Le Hello1, Elisabeth Delarocque-Astagneau1, on behalf of the BIRDY study group
Author affiliations: Institut Pasteur, Paris, France (M. Nadimpalli, L. Fabre, A. Criscuolo, B.-T. Huynh, D. Guillemot, S. Le Hello, E. Delarocque-Astagneau); Institut National de la Santé et de la Recherche Médicale, Université de Versailles Saint-Quentin-en-Yvelines and Université Paris-Saclay, Paris (M. Nadimpalli, B.-T. Huynh, D. Guillemot, E. Delarocque-Astagneau); Institut Pasteur du Cambodge, Phnom Penh, Cambodia (Y. Vuthy, A. de Lauzanne, M. Gouali, L. Borand, A. Kerléguer, P. Piola); Assistance Publique/Hôpitaux de Paris, Bicêtre Hospital and Université Paris-Sud, Le Kremlin-Bicêtre, France (T. Naas); Sihanouk Hospital Center of Hope, Phnom Penh (T. Phe); Institute of Tropical Medicine, Antwerp, Belgium (J. Jacobs); K.U. Leuven, Leuven, Belgium (J. Jacobs); Assistance Publique/Hôpitaux de Paris, Raymond-Poincaré Hospital, Garches, France (D. Guillemot, E. Delarocque-Astagneau)

Main Article

Figure 2

Genomic comparisons of extended-spectrum β-lactamase (ESBL)–producing Escherichia coli from humans, fish, pork, and chicken from Cambodia and differences in human colonization isolates by phylogenetic clan. All isolates were phenotypically resistant to third-generation cephalosporins (data not shown). A) Whole-genome sequence-based phylogenetic tree of 195 ESBL-producing E. coli genomes comprising 87 human colonization isolates, 15 human clinical isolates, and 93 isolates from fish, pork, and ch

Figure 2. Genomic comparisons of extended-spectrum β-lactamase (ESBL)–producing Escherichia coli from humans, fish, pork, and chicken from Cambodia and differences in human colonization isolates by phylogenetic clan. All isolates were phenotypically resistant to third-generation cephalosporins (data not shown). A) Whole-genome sequence-based phylogenetic tree of 195 ESBL-producing E. coli genomes comprising 87 human colonization isolates, 15 human clinical isolates, and 93 isolates from fish, pork, and chicken meat and resulting phylogenetic clans I/B2&D (n = 53), II/A (n = 69), and III/B1 (n = 47). B) ESBL-encoding genes of human colonization E. coli isolates, by phylogenetic clan. C) Phenotypic resistance of human colonization ESBL-producing E. coli isolates to antimicrobial drugs of 8 classes, by phylogenetic clan. Clinical isolates are not included in panels B or C. Of 87 human colonization genomes, 13 did not group into a phylogenetic clan and thus are excluded from panels B and C. Prevalence of outcome differed significantly (p<0.05, indicated by *) between 2 indicated clans by post hoc Tukey test. Only statistically significant differences are depicted. 1, quinolone; 2, co-trimoxazole; 3, tetracycline; 4, aminoglycoside; 5, macrolide; 6, amphenicol; 7, carbapenem; 8, colistin.

Main Article

1These senior authors contributed equally to this article.

2Additional members of the BIRDY study group are listed at the end of this article.

Page created: December 17, 2018
Page updated: December 17, 2018
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