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Volume 25, Number 1—January 2019
CME ACTIVITY - Research

Prescription of Antibacterial Drugs for HIV-Exposed, Uninfected Infants, Malawi, 2004–2010

Alexander C. EwingComments to Author , Nicole L. Davis, Dumbani Kayira, Mina C. Hosseinipour, Charles van der Horst, Denise J. Jamieson, Athena P. Kourtis, and for the BreastfeedingAntiretrovirals and Nutrition study team
Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA (A.C. Ewing, N.L. Davis, D.J. Jamieson, A.P. Kourtis); University of North Carolina Project, Lilongwe, Malawi (D. Kayira); University of North Carolina, Chapel Hill, North Carolina, USA (M.C. Hosseinipour, C. van der Horst)

Main Article

Table 4

Antibacterial prescriptions and person-time of follow-up for HIV-exposed, uninfected infants in the Breastfeeding, Antiretrovirals and Nutrition study, Malawi, 2004–2010*

Variable
 Overall
Before CPT
After CPT
p values†
Total no.
 Per person
 Per infant-month
 Total no.
 Per person
 Per infant-month
 Total no.
 Per person
 Per infant-month
 Per person
 Per person-month
No.
2,152
692
1,460
Median follow-up time, d
 600,562
 336 (255–340)
187,865
 337 (226–343)
412,697
 336 (294–339)
0.09
Prescriptions, total 5,107 2 (1–3) 0.2 (0.1–0.3) 2,269 3 (1–5) 0.3 (0.2–0.5) 28,38 2 (1–3) 0.2 (0.1–0.3) <0.0001 <0.0001
For respiratory infections 3,437 1 (0–2) 0.1 (0–0.2) 1481 2 (1–3) 0.2 (0.1–0.3) 1956 1 (0–2) 0.1 (0.0–0.2) <0.0001 <0.0001
For other infections 1,670 0 (0–1) 0 (0–0.1) 788 1 (0–2) 0.1 (0–0.2) 882 0 (0–1) 0.0 (0.0–0.1) <0.0001 <0.0001

*Overall and according to baseline visit timing relative to CPT guideline implementation (June, 2006). Values are range (IQR) except as indicated. CPT, cotrimoxazole prophylaxis; IQR, interquartile range.
†p values based on Kruskal-Wallis test for continuous variables.

Main Article

1Team members are listed at the end of this article.

Page created: December 12, 2018
Page updated: December 12, 2018
Page reviewed: December 12, 2018
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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