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Volume 25, Number 11—November 2019
Dispatch

Clinical REsearch During Outbreaks (CREDO) Training for Low- and Middle-Income Countries

Nzelle Delphine KayemComments to Author , Amanda Rojek, Emmanuelle Denis, Alex Salam, Andreas Reis, Piero Olliaro, and Peter Horby
Author affiliations: University of Oxford, Oxford, UK (N.D. Kayem, A. Rojek, E. Denis, A. Salam, P. Olliaro, P. Horby); United Kingdom Public Health Rapid Support Team, Oxford (A. Salam); World Health Organization, Geneva, Switzerland (A. Reis)

Main Article

Table 2

Curriculum structure of Clinical REsearch During Outbreaks (CREDO) training course

Module title Module summary and website link
Prerequisite modules
Good clinical practice A framework of principles to ensure the safety of research participants and integrity and validity of data: https://globalhealthtrainingcentre.tghn.org/ich-good-clinical-practice
The global health research process map
 A pragmatic interactive tool provides step-by-step guidance for each stage that needs to be considered when planning a new study: https://processmap.tghn.org/about
Workshop: Evidence-based medicine for epidemic infections and key issues in study design
 Delivered in 3 presentations, it provides an introduction to epidemic and emerging infections, critiques the clinical research responses to previous outbreaks, highlights the challenges to clinical research during outbreaks, and discusses possible mitigating strategies: https://isaric.tghn.org/credo/credo-workshop-1
E-learning component: self-paced, in any order, completed individually before the second workshop
Rapid evidence-needs appraisal A guide for the conduct of rapid reviews in the event of an outbreak: https://globalhealthtrainingcentre.tghn.org/credo-rapid-evidence-needs-appraisal
Research study planning and governance An overview of how to set up a clinical research study and find and apply for funding, and important concepts for study managements: https://globalhealthtrainingcentre.tghn.org/credo-research-study-planning-and-governance
Study design An introduction to the challenges to research design during outbreaks and some mitigating strategies: https://globalhealthtrainingcentre.tghn.org/credo-study-design
Statistics Background of statistical principles relevant to clinical research and trial design and challenges in outbreaks and some solutions: https://globalhealthtrainingcentre.tghn.org/credo-statistics
Logistics and operational planning Pragmatic solutions to common logistical and operational challenges to research in outbreaks: https://globalhealthtrainingcentre.tghn.org/credo-logistical-and-operational-planning
Data sharing and harmonization General outline of data management, sharing, and harmonization to guide the conduct of research during outbreaks: https://isaric.tghn.org/credo/credo-data-sharing-and-harmonisation
Ethics WHO course on ethics in outbreaks; modules 2, 4, and 6 on the TGHN platform: https://globalhealthtrainingcentre.tghn.org/research-ethics-epidemics-pandemics-and-disaster-situations
Communications and engagement Effective communication and engagement during outbreaks: https://globalhealthtrainingcentre.tghn.org/credo-communications-and-community-engagement
Special groups: Children, pregnant women, 
mother/child
 A consensus statement on the inclusion of children and pregnant women in research in disease outbreaks to help facilitate including these important groups in future research and clinical trials: https://isaric.tghn.org/credo/ethics-special-groups
Workshop: final assessment, completed in teams

*Prerequisite modules must be completed online individually before the first workshop. TGHN, The Global Health Network; WHO, World Health Organization.

Main Article

Page created: October 15, 2019
Page updated: October 15, 2019
Page reviewed: October 15, 2019
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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