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Volume 25, Number 11—November 2019
Research Letter

Drug-Susceptible and Multidrug-Resistant Mycobacterium tuberculosis in a Single Patient

Anthony Baffoe-Bonnie, Eric R. Houpt, Lauren Turner, Denise Dodge, and Scott K. HeysellComments to Author 
Author affiliations: Virginia Polytechnic Institute and State University Carilion School of Medicine, Roanoke, Virginia, USA (A. Baffoe-Bonnie); University of Virginia, Charlottesville, Virginia, USA (E.R. Houpt, S.K. Heysell); Division of Consolidated Laboratory Services, Richmond, Virginia, USA (L. Turner); Virginia Department of Health, Richmond (D. Dodge)

Main Article

Table

Characteristics of cases of treatment failure resulting from concurrent infection with mixed strains of drug-resistant Mycobacterium tuberculosis*

Patient age, y/sex Immune status Site(s) of infection Time to recurrence Platform for strain identification Patient country of origin Country of diagnosis Reference
24/M
Immunocompetent
Lymph node, gastric aspirate
100 d
Mixed-linker fingerprint PCR
Nepal
Germany
(1)
23/M
HIV negative
Pulmonary
150 d
Spoligotyping and MIRU
Somalia
USA
(4)
24/M
HIV negative
Pulmonary, gastric aspirate
90 d
IS6110 RFLP and spoligotyping
Kazakhstan
Germany
(2)
62/M
HIV negative
Pulmonary
120 d
MIRU-VNTR
Portugal
UK
(3)
28/M HIV positive Lymph node, trachea 84 d Spoligotyping and WGS Philippines USA This study

*IS, insertion sequence; MIRU-VNTR, mycobacterial interspersed repetitive unit–variable number tandem repeat; RFLP, restriction fragment length polymorphism; WGS, whole genome sequencing.

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References
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Page created: October 15, 2019
Page updated: October 15, 2019
Page reviewed: October 15, 2019
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