Volume 25, Number 2—February 2019
Perspective
International Biological Reference Preparations for Epidemic Infectious Diseases
Tommy Rampling
, Mark Page, and Peter Horby
, Mark Page, and Peter Horby
Table 2
Revised list of World Health Organization priority diseases, February 2018*
| Disease or pathogen | Current development status of international reference preparations |
|---|---|
| Crimean-Congo hemorrhagic fever |
None available. Source material required. |
| Ebola virus disease and Marburg virus disease |
Ebola virus antibody and NA IRPs available. VP40 antigen in development. No other filovirus IRPs available. Source material required. |
| Lassa fever |
None available. Source material required. |
| MERS-CoV and SARS |
Antibody and NA IRPs in development for MERS-CoV. Additional source material required. |
| Nipah virus and related henipavirus diseases |
None available. Source material required. |
| Rift Valley fever |
None available. Source material required. |
| Zika |
NA and antibody IRPs available. |
| Disease X† |
Not applicable. |
| Diseases or pathogens considered for inclusion on priority pathogen list and under annual review | |
| Arenavirus hemorrhagic fevers other than Lassa fever | None available. Source material required. |
| Chikungunya | None available. |
| Highly pathogenic coronavirus diseases other than MERS-CoV and SARS | None available. Source material required. |
| Emergent nonpolio enteroviruses (including EV71, D68) | EV71 antibody IRP available. No other nonpolio enterovirus IRPs available. Source material required. |
| Severe fever with thrombocytopenia syndrome | None available. Source material required. |
*EV, enterovirus; IRP, international reference preparation; MERS-CoV, Middle East respiratory syndrome coronavirus; NA, nucleic acid; SARS, severe acute respiratory syndrome; VP, virus protein.
†Any disease identified before the next review by using the blueprint decision instrument will be included in the list.
Page created: January 18, 2019
Page updated: January 18, 2019
Page reviewed: January 18, 2019
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