Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 25, Number 2—February 2019
Research

Zika Virus IgM Detection and Neutralizing Antibody Profiles 12–19 Months after Illness Onset

Isabel GriffinComments to Author , Stacey W. Martin, Marc Fischer, Trudy V. Chambers, Olga Kosoy, Alyssa Falise, Olga Ponomareva, Leah D. Gillis, Carina Blackmore, and Reynald Jean
Author affiliations: Florida Department of Health in Miami–Dade County, Miami, Florida, USA (I. Griffin, A. Falise, O. Ponomareva, R. Jean); Centers for Disease Control and Prevention, Fort Collins, Colorado, USA (S.W. Martin, M. Fischer, T.V. Chambers, O. Kosoy); Bureau of Public Health Laboratories, Miami (L.D. Gillis); Florida Department of Health, Tallahassee, Florida, USA (C. Blackmore)

Main Article

Table 3

Diagnostic test interpretations among participants with PCR-confirmed Zika virus disease in Miami–Dade County, Florida, USA, based on IgM and neutralizing antibody results 12–19 months after onset*

Test results No. (%), n = 62 Interpretation†
Zika virus IgM positive or equivocal, n = 57
Zika virus PRNT titer >10 and DENV PRNT titer <10 21 (34) Recent Zika virus infection
Zika virus PRNT titer >4-fold higher than DENV PRNT titer 21 (34) Recent flavivirus infection
<4-fold difference between Zika virus and DENV PRNT titers 11 (18) Recent flavivirus infection
DENV PRNT titer >4-fold higher than Zika virus PRNT titer
 4 (6)
 Recent flavivirus infection
ZIKV IgM negative, n = 5
Zika virus PRNT titer >10 and Zika virus PRNT titer <10 2 (3) Previous Zika virus infection
Zika virus PRNT titer >4-fold higher than DENV PRNT titer 1 (2) Previous flavivirus infection
<4-fold difference between Zika virus and DENV PRNT titers 1 (2) Previous flavivirus infection
DENV PRNT titer >4-fold higher than Zika virus PRNT titer 1 (2) Previous flavivirus infection

*DENV, dengue virus; PRNT, plaque reduction neutralization test.
†Recent Zika virus infection: Zika virus IgM positive or equivocal with a Zika virus PRNT titer ≥10 and dengue PRNT titer <10; recent flavivirus infection: Zika virus IgM positive or equivocal with a Zika virus PRNT titer >10 or dengue PRNT titer >10; previous Zika virus infection: Zika virus IgM negative with a Zika virus PRNT titer ≥10 and dengue PRNT titer <10; previous flavivirus infection: Zika virus IgM negative with a Zika virus PRNT titer >10 or dengue PRNT titer >10.

Main Article

Page created: January 16, 2019
Page updated: January 16, 2019
Page reviewed: January 16, 2019
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external