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Volume 25, Number 3—March 2019
Dispatch

In Vivo Selection of a Unique Tandem Repeat Mediated Azole Resistance Mechanism (TR120) in Aspergillus fumigatus cyp51A, Denmark

Rasmus K. HareComments to Author , Jan B. Gertsen, Karen M.T. Astvad, Kristine B. Degn, Anders Løkke, Marc Stegger, Paal S. Andersen, Lise Kristensen, and Maiken C. ArendrupComments to Author 
Author affiliations: Statens Serum Institut, Copenhagen, Denmark (R.K. Hare, K.M.T. Astvad, M. Stegger, P.S. Andersen, M.C. Arendrup); Åarhus University Hospital, Åarhus, Denmark (J.B. Gertsen, K.B. Degn, A. Løkke, L. Kristensen); Rigshospitalet, Copenhagen (M.C. Arendrup); University of Copenhagen, Copenhagen (M.C. Arendrup)

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Figure 2

Unrooted phylogenetic tree based on whole-genome sequencing of 2 patient isolates (P-1 and P-3) and 5 reference strains to highlight relatedness between Aspergillus fumigatus isolates, Denmark, 2018. We inferred relatedness by using FastTree version 2.1 (7) based on a 77.69% core genome. Whole-genome sequencing identified 41 single-nucleotide polymorphism (SNP) differences between P-1 and P-3. We observed subtle differences (<5,000 SNPs) between unrelated patient isolate SSI-5197 and P-1/P-3,

Figure 2. Unrooted phylogenetic tree based on whole-genome sequencing of 2 patient isolates (P-1 and P-3) and 5 reference strains to highlight relatedness between Aspergillus fumigatus isolates, Denmark, 2018. We inferred relatedness by using FastTree version 2.1 (7) based on a 77.69% core genome. Whole-genome sequencing identified 41 single-nucleotide polymorphism (SNP) differences between P-1 and P-3. We observed subtle differences (<5,000 SNPs) between unrelated patient isolate SSI-5197 and P-1/P-3, whereas >100,000 SNPs differed from P-1/P-3 to the other control strains and Af293. WT, wild-type.

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Page created: February 19, 2019
Page updated: February 19, 2019
Page reviewed: February 19, 2019
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