Exportation of MDR TB to Europe from Setting with Actively Transmitted Persistent Strains in Peru
Fermín Acosta, Juan Agapito, Andrea Maurizio Cabibbe, Tatiana Cáceres, Christophe Sola, Laura Pérez-Lago, Estefanía Abascal, Marta Herranz, Erika Meza, Bernice Klotoe, Patricia Muñoz, Gian María Rossolini, Alessandro Bartoloni, Enrico Tortoli, Daniela María Cirillo, Eduardo Gotuzzo, and Darío García de Viedma
Author affiliations: Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain (F. Acosta, L. Pérez-Lago, E. Abascal, M. Herranz, P. Muñoz, D. García de Viedma); Hospital General Universitario Gregorio Marañón Servicio de Microbiología, Madrid (F. Acosta, L. Pérez-Lago, E. Abascal, M. Herranz, P. Muñoz, D. García de Viedma); Instituto de Medicina Tropical Alexander von Humboldt, Lima, Peru (J. Agapito, T. Cáceres, E. Meza, E. Gotuzzo); Universidad Peruana Cayetano Heredia, Lima, Peru (J. Agapito, T. Cáceres, E. Meza, E. Gotuzzo); Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele Scientific Institute, Milan, Italy (A.M. Cabibbe, E. Tortoli, D.M. Cirillo); Institute for Integrative Biology of the Cell, CEA, CNRS, Université Paris‐Sud, Université Paris-Saclay, Gif-Sur-Yvette, France (C. Sola, B. Klotoe); Centro de Investigación Biomédica en Red Enfermedades Respiratorias, Madrid (M. Herranz, P. Muñoz, D. García de Viedma); Florence Careggi University Hospital, Florence, Italy (G.M. Rossolini); Careggi Hospital, Florence (A. Bartoloni)
Figure. Median-joining network of whole-genome sequenced isolates of strain C8-LPMDR found in Italy, Peru, and Spain, 2007–2017. Network 22.214.171.124 (http://www.fluxus-engineering.com) was used to perform network analysis. Each dot along the lines linking isolates corresponds to a single-nucleotide polymorphism difference. Isolates within the same box share identical sequences. mv1 corresponds to an unsampled case inferred from the network topology. Sequences were deposited in the European Bioinformatics Institute database (http://www.ebi.ac.uk, accession no. PRJEB25765). FL, Florence; IT, Italy; MRCA, most recent common ancestor.
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