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Volume 25, Number 3—March 2019
Dispatch

Neutralizing Antibody against Enterovirus D68 in Children and Adults before 2014 Outbreak, Kansas City, Missouri, USA1

Christopher J. HarrisonComments to Author , William C. Weldon2, Barbara A. Pahud2, Mary Anne Jackson2, M. Steven Oberste2, and Rangaraj Selvarangan2
Author affiliations: The Children’s Mercy Hospital, Kansas City, Missouri, USA (C.J. Harrison, B.A. Pahud, M.A. Jackson, R. Selvarangan); University of Missouri at Kansas City, Kansas City (C.J. Harrison, B.A. Pahud, M.A. Jackson, R. Selvarangan); Centers for Disease Control and Prevention, Atlanta, Georgia, USA (W.C. Weldon, M.S. Oberste)

Main Article

Figure 1

Unrooted neighbor-joining tree depicting phylogenetic relatedness of reference enterovirus D68 isolates (black circles) used in microneutralization assays in study of enterovirus D68 seroprevalence among children and adults in Kansas City, Missouri, USA, 2012–2013. We constructed tree using complete virus protein 1 gene sequences and MEGA6.0 (8). Branching within major clades (bolded) is collapsed for clarity.

Figure 1. Unrooted neighbor-joining tree depicting phylogenetic relatedness of reference enterovirus D68 isolates (black circles) used in microneutralization assays in study of enterovirus D68 seroprevalence among children and adults in Kansas City, Missouri, USA, 2012–2013. We constructed tree using complete virus protein 1 gene sequences and MEGA6.0 (8). Branching within major clades (bolded) is collapsed for clarity.

Main Article

References
  1. Schieble  JH, Fox  VL, Lennette  EH. A probable new human picornavirus associated with respiratory diseases. Am J Epidemiol. 1967;85:297310. DOIPubMedGoogle Scholar
  2. Oberste  MS, Maher  K, Schnurr  D, Flemister  MR, Lovchik  JC, Peters  H, et al. Enterovirus 68 is associated with respiratory illness and shares biological features with both the enteroviruses and the rhinoviruses. J Gen Virol. 2004;85:257784. DOIPubMedGoogle Scholar
  3. Khetsuriani  N, Lamonte-Fowlkes  A, Oberst  S, Pallansch  MA; Centers for Disease Control and Prevention. Enterovirus surveillance—United States, 1970-2005. MMWR Surveill Summ. 2006;55:120.PubMedGoogle Scholar
  4. Midgley  CM, Watson  JT, Nix  WA, Curns  AT, Rogers  SL, Brown  BA, et al.; EV-D68 Working Group. Severe respiratory illness associated with a nationwide outbreak of enterovirus D68 in the USA (2014): a descriptive epidemiological investigation. Lancet Respir Med. 2015;3:87987. DOIPubMedGoogle Scholar
  5. Schuster  JE, Miller  JO, Selvarangan  R, Weddle  G, Thompson  MT, Hassan  F, et al. Severe enterovirus 68 respiratory illness in children requiring intensive care management. J Clin Virol. 2015;70:7782. DOIPubMedGoogle Scholar
  6. Wallace  GS, Pahud  BA, Weldon  WC, Curns  AT, Oberste  MS, Harrison  CJ. Seroprevalence of poliovirus antibodies in the Kansas City metropolitan area, 2012-2013. Hum Vaccin Immunother. 2017;13:77683. DOIPubMedGoogle Scholar
  7. Weldon  WC, Oberste  MS, Pallansch  MA. Standardized methods for detection of poliovirus antibodies. In: Martin JM, editor. Methods in molecular biology. Vol. 1378. New York: Humana Press; 2016. p. 145–76.
  8. Tamura  K, Stecher  G, Peterson  D, Filipski  A, Kumar  S. MEGA6: Molecular Evolutionary Genetics Analysis version 6.0. Mol Biol Evol. 2013;30:27259. DOIPubMedGoogle Scholar
  9. Brown  BA, Nix  WA, Sheth  M, Frace  M, Oberste  MS. Seven strains of enterovirus D68 detected in the United States during the 2014 severe respiratory disease outbreak. Genome Announc. 2014;2:e01201-14. DOIPubMedGoogle Scholar
  10. Huang  W, Wang  G, Zhuge  J, Nolan  SM, Dimitrova  N, Fallon  JT. Whole-genome sequence analysis reveals the enterovirus D68 isolates during the United States 2014 outbreak mainly belong to a novel clade. Sci Rep. 2015;5:15223. DOIPubMedGoogle Scholar
  11. Wang  SM, Liu  CC. Update of enterovirus 71 infection: epidemiology, pathogenesis and vaccine. Expert Rev Anti Infect Ther. 2014;12:44756. DOIPubMedGoogle Scholar
  12. Looi  K, Buckley  AG, Rigby  PJ, Garratt  LW, Iosifidis  T, Zosky  GR, et al. Effects of human rhinovirus on epithelial barrier integrity and function in children with asthma. Clin Exp Allergy. 2018;48:51324. DOIPubMedGoogle Scholar
  13. Xiang  Z, Li  L, Ren  L, Guo  L, Xie  Z, Liu  C, et al. Seroepidemiology of enterovirus D68 infection in China. Emerg Microbes Infect. 2017;6:e32. DOIPubMedGoogle Scholar
  14. Aliabadi  N, Messacar  K, Pastula  DM, Robinson  CC, Leshem  E, Sejvar  JJ, et al. Enterovirus D68 infection in children with acute flaccid myelitis, Colorado, USA, 2014. Emerg Infect Dis. 2016;22:138794. DOIPubMedGoogle Scholar

Main Article

1Preliminary results from this study were presented at the Clinical Virology Symposium, May 19–22, 2016, Daytona Beach, Florida, USA.

2These authors contributed equally to this article.

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Page updated: February 19, 2019
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