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Volume 25, Number 3—March 2019

Dispatch

Neutralizing Antibody against Enterovirus D68 in Children and Adults before 2014 Outbreak, Kansas City, Missouri, USA1

Christopher J. HarrisonComments to Author , William C. Weldon2, Barbara A. Pahud2, Mary Anne Jackson2, M. Steven Oberste2, and Rangaraj Selvarangan2
Author affiliations: The Children’s Mercy Hospital, Kansas City, Missouri, USA (C.J. Harrison, B.A. Pahud, M.A. Jackson, R. Selvarangan); University of Missouri at Kansas City, Kansas City (C.J. Harrison, B.A. Pahud, M.A. Jackson, R. Selvarangan); Centers for Disease Control and Prevention, Atlanta, Georgia, USA (W.C. Weldon, M.S. Oberste)

Main Article

Table

Neutralizing antibody positivity and titers for each enterovirus D68 isolate, by age group, Kansas City, Missouri, 2012–2013

Age group, y No. % Neutralizing antibody positive; median (range) neutralizing antibody titer*
Fermon 14-18949 14-18952 14-18953
2–5 79 100; 5.50 (3.17–9.5) 100; 5.83 (3.5–10.5) 60; 3.17 (2.5–10.5) 81; 4.17 (2.5–10.5)
6–10 97 100; 6.17 (3.17–10.5) 100; 7.83 (4.17–10.5) 89; 7.83 (2.5–10.5) 83; 6.17 (2.5–10.5)
11–15 91 100; 5.83 (3.17–10.5) 100; 7.83 (3.17–10.5) 97; 8.50 (2.5–10.5) 93; 6.50 (2.5–10.5)
16–50 84 100; 8.50 (3.83–10.5) 100; 8.50 (4.83–10.5) 98; 9.17 (2.5–10.5) 96; 7.17 (2.5–10.5)
>50
 85
 100; 10.50 (6.5–10.5)
 100; 8.83 (4.83–10.5)
 99; 9.50 (2.5–10.5)
 98; 6.83 (2.5–10.5)
Total 436 100; 6.83 (2.83–10.5) 100; 7.83 (3.5–10.5) 89; 8.34 (2.5–10.5) 91; 6.50 (2.5–10.5)

*Antibody titers were measured by using the cell viability kit ATPlite (Perkin Elmer, http://www.perkinelmer.com); the titers shown are the log2 inverse dilution of the lowest antibody concentration with luminescent activity.

Main Article

1Preliminary results from this study were presented at the Clinical Virology Symposium, May 19–22, 2016, Daytona Beach, Florida, USA.

2These authors contributed equally to this article.

Page created: February 19, 2019
Page updated: February 19, 2019
Page reviewed: February 19, 2019
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