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Volume 25, Number 3—March 2019
Synopsis

Cross-Border Movement of Highly Drug-Resistant Mycobacterium tuberculosis from Papua New Guinea to Australia through Torres Strait Protected Zone, 2010–2015

Arnold Bainomugisa, Sushil Pandey, Ellen Donnan, Graham Simpson, J’Belle Foster, Evelyn Lavu, Stenard Hiasihri, Emma S. McBryde, Rendi Moke, Steven Vincent, Vitali Sintchenko, Ben J. Marais, Lachlan J.M. Coin, and Christopher CoulterComments to Author 
Author affiliations: Pathology Queensland, Brisbane, Queensland, Australia (A. Bainomugisa, S. Pandey, C. Coulter); The University of Queensland, Brisbane (A. Bainomugisa, L.J.M. Coin); Queensland Department of Health, Brisbane (E. Donnan, C. Coulter); Cairns Tuberculosis Unit, Cairns, Queensland, Australia (G. Simpson, S. Vincent); James Cook University, Townsville, Queensland, Australia (J. Foster, E.S. McBryde); Central Public Health Laboratory, Port Moresby, Papua New Guinea (E. Lavu); Western Province Health Office, Daru, Papua New Guinea (S. Hiasihri); Port Moresby General Hospital, Port Moresby (R. Moke); Westmead Hospital, Sydney, New South Wales, Australia (V. Sintchenko); The University of Sydney, Sydney (V. Sintchenko, B.J. Marais)

Main Article

Table 2

Characteristics associated with Mycobacterium tuberculosis isolate clustering among Papua New Guinea residents, Torres Strait Protected Zone, 2010–2015*

Characteristic No. clustered/total no. OR (95% CI) p value aOR (95% CI)† p value
Beijing lineage 74/100
No 9/21 Referent Referent
Yes
 65/79
 6.190 (2.221–18.077)
 0.0005
 4.484 (1.526–13.891)
 0.007
Age, y
<15 14/19 Referent Referent
15–24 25/31 1.488 (0.369–5.841) 0.565 1.298 (0.291–5.614) 0.725
25–34 19/24 1.357 (0.320–5.783) 0.673 1.242 (0.260–5.981) 0.782
35–49 12/18 0.714 (0.166–2.955) 0.641 0.722 (0.148–3.415) 0.679
>50
 4/8
 0.357 (0.059–2.016)
 0.241
 0.262 (0.035–1.785)
 0.173
Sex
F 34/45 Referent Referent
M
 40/55
 0.862 (0.343–2.118)
 0.748
 0.856 (0.311–2.284)
 0.757
Sputum smear
Negative 32/46 Referent Referent
Positive
 42/54
 1.531 (0.624–3.808)
 0.352
 1.147 (0.423–3.095)
 0.784
Case type
New case 63/87 Referent Referent
Recurrent
 11/13
 2.095 (0.513–14.183)
 0.358
 1.447 (0.270–11.282)
 0.684
Diagnostic delay, d
0–30 40/53 Referent Referent
31–59 13/18 0.845 (0.260–3.033) 0.784 1.042 (0.290–4.154) 0.95
>60
 21/29
 0.853 (0.308–2.455)
 0.761
 1.157 (0.380–3.743)
 0.799
MDR or XDR
No 46/69 Referent Referent
Yes
 28/31
 4.677 (1.452–20.943)
 0.019
 2.774 (0.779–13.123)
 0.143
Treatment outcome
Cure, treatment completed 13/22 Referent Referent
Transferred, lost to follow-up 50/66 2.163 (0.767–6.006) 0.138 1.794 (0.584–5.407) 0.298
Defaulted 2/3 NA NA NA NA
Died 9/9 NA NA NA NA

*aOR, adjusted OR; MDR, multidrug resistant; NA, not applicable (large value); OR, odds ratio; XDR, extensively drug resistant.
†Adjusted for Beijing lineage and drug resistance (MDR or XDR).

Main Article

Page created: February 19, 2019
Page updated: February 19, 2019
Page reviewed: February 19, 2019
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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