Volume 25, Number 3—March 2019
Research
Emergence and Spread of Cephalosporin-Resistant Neisseria gonorrhoeae with Mosaic penA Alleles, South Korea, 2012–2017
Hyukmin Lee, Young Hee Suh, Sunhwa Lee, Yong-Kyun Kim, Mi-Soon Han, Hye Gyung Bae, Magnus Unemo1
, and Kyungwon Lee1
, and Kyungwon Lee1
Table 2
Molecular typing of specimens positive for a Neisseria gonorrhoeae mosaic penA allele by year, South Korea, 2012–2017*
| Year | No. (%) specimens with mosaic penA | Mosaic penA allele (no. specimens) | MLST ST (no. specimens) | NG-MAST ST (no. specimens) |
|---|---|---|---|---|
| 2012 |
5 (1.2) |
10.001 (5) |
1901 (5) |
2958 (5) |
| 2013 |
27 (5.2) |
10.001 (17) | 1901 (21) | 2958 (8), 10668 (6), 5682 (1), 6783 (1), 10669 (1) |
| 72.001 (4) | 1407 (3), 436 (1) | |||
| 10.001 (1) | 7363 (1) | 5308 (1) | ||
| 10.001 (3) | ND (5) |
ND (3) | ||
| 34.001 (2) |
10670 (1), ND (1) |
|||
| 2014 |
60 (9.9) |
10.001 (1) | 1588 (1) | 6696 (1) |
| 10.001 (54) | 1901 (56) | 10668 (33), 2958 (15), 11495 (2), 11493 (1), 11494 (1), 11496 (1), 11497 (1) | ||
| 34.001 (1) | 5622 (1) | |||
| 72.001 (1) | 1407 (1) | |||
| 10.001 (3) |
ND (3) |
ND (3) |
||
| 2015 |
109 (18.0) |
10.001 (2) | 1579 (2) | 13376 (2) |
| 10.001 (7) | 1588 (7) | 12399 (3), 3611 (2), 6696 (1), 10679 (1) | ||
| 10.001 (82) | 1901 (82) | 10668 (38), 2958 (20), 6734 (7), 11495 (4), 1407 (3), 6481 (3), 4502 (2), 6373 (2), 11497 (1), 13374 (1), 13388 (1), 13391 (1) | ||
| 10.001 (1) | 1922 (1) | 13393 (1) | ||
| 10.001 (10) | 7363 (10) | 5308 (8), 11562 (1), 13389 (1) | ||
| 10.001 (2) | 7371 (2) | 13390 (1), 13394 (1) | ||
| 34.001 (2) | 7827 (2) | 3702 (2) | ||
| 10.001 (2) | 8137 (2) | 13373 (1), 13392 (1) | ||
| 10.001 (1) |
10931 (1) |
12402 (1) |
||
| 2016 |
185 (22.5) |
10.001 (11) | 1588 (11) | 15024 (7), 15026 (3), 15086 (1) |
| 10.001 (133) | 1901 (148) | 15014 (39), 15016 (31), 15015 (28), 7307 (8), 15025 (3), 15041 (3), 15029 (2), 15045 (2), 11497 (1), 15013 (1), 15017 (1), 15018 (1), 15019 (1), 15020 (1), 15021 (1), 15022 (1), 15023 (1), 15027 (1), 15031 (1), 15033 (1), 15034 (1), 15038 (1), 15042 (1), 15044 (1), 15048 (1) | ||
| 27.001 (2) | 15015 (2) | |||
| 34.001 (3) | 4431 (1), 15032 (1), 15039 (1) | |||
| 72.001 (10) | 15018 (7), 4431 (1), 15016 (1), 15030 (1) | |||
| 10.001 (26) |
7363 (26) |
6910 (13), 15028 (4), 15037 (2), 15046 (2), 15012 (1), 15040 (1), 15043 (1), 15049 (1), 15050 (1) |
||
| 2017 | 215 (23.9) | 10.001 (40) | 1588 (40) | 15024 (24), 5576 (4), 3611 (3), 15025 (3), 15026 (2), 6696 (1), 7684 (1), 14668 (1), 16331 (1) |
| 10.001 (143) | 1901 (145) | 15014 (33), 15016 (25), 7307 (17), 15015 (16), 5446 (10), 15032 (3), 16324 (3), 16341 (3), 6734 (2), 15045 (2), 16270 (2), 16325 (2), 16335 (2), 12402 (1), 13973 (1), 15018 (1), 15019 (1), 15028 (1), 15029 (1), 16319 (1), 16320 (1), 16321 (1), 16323 (1), 16328 (1), 16329 (1), 16332 (1), 16333 (1), 16334 (1), 16336 (1), 16338 (1), 16342 (1), 16343 (1), 16344 (1), 16346 (1) | ||
| 34.001 (2) | 15032 (2) | |||
| 10.001 (1) | 1902 (1) | 16339 (1) | ||
| 60.001 (1) | 1903 (1) | 16327 (1) | ||
| 10.001 (24) | 7363 (25) | 6910 (13), 16322 (3), 13044 (1), 13876 (1), 15037 (1), 15046 (1), 16318 (1), 16337 (1), 16340 (1) | ||
| 34.001 (1) | 11624 (1) | |||
| 10.001 (1) | 7371 (1) | 16330 (1) | ||
| 10.001 (1) | 10899 (1) | 11895 (1) | ||
| 10.001 (1) | 11179 (1) | 16345 (1) |
*MLST, multilocus sequence typing; ND, not determined (due to insufficient amount of DNA); NG-MAST, N. gonorrhoeae multiantigen sequence typing; ST, sequence type.
1Joint senior authors.
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