Volume 25, Number 3—March 2019
Research
Window Period Prophylaxis for Children Exposed to Tuberculosis, Houston, Texas, USA, 2007–2017
Andrea T. Cruz
and Jeffrey R. Starke
and Jeffrey R. Starke
Table 2
Association between epidemiologic and microbiologic variables and tuberculin skin test conversion among children exposed to index tuberculosis patients, Houston, Texas, USA, 2007–2017
| Variable | Tuberculin skin test conversion* |
Value† | |
|---|---|---|---|
| Converted, no. (%), n = 37 | Not converted, no. (%), n = 715 | ||
| Child demographics | |||
| Age, y | |||
| 0–<1 | 4/154 (2.6) | 150/154 (97.4) | Referent |
| 1–<2 | 8/164 (4.9) | 156/164 (95.1) | 1.9 (0.6–6.5) |
| 2–<5 | 25/434 (5.8) | 409/434 (94.2) | 2.3 (0.8–6.7) |
| Sex | |||
| F | 21/380 (5.5) | 359/380 (94.5) | Referent |
| M | 16/372 (4.3) | 356/372 (95.7) | 0.8 (0.4–1.5) |
| Race/ethnicity | |||
| Hispanic | 24/493 (4.9) | 469/493 (95.1) | Referent |
| Black | 5/141 (3.5) | 136/141 (96.5) | 0.7 (0.3–1.9) |
| Asian | 4/78 (5.1) | 74/78 (94.9) | 1.1 (0.4–3.1) |
| Other |
4/40 (10) |
36/40 (90) |
2.1 (0.7–6.6) |
| Index patient demographics | |||
| Age, y | 37 | 46 | p = 0.002 |
| Relationship to child | |||
| Grandparent | 8/284 (2.8) | 276/284 (97.2) | Referent |
| Parent | 10/119 (8.4) | 109/119 (91.6) | 3.2 (1.2–8.2) |
| Other relative | 13/255 (5.1) | 242/255 (94.9) | 0.7 (0.3–1.8) |
| Nonrelative | 6/94 (6.4) | 88/94 (93.6) | 0.9 (0.3–2.8) |
| Household member of child | |||
| No | 17/441 (3.9) | 424/441 (96.1) | Referent |
| Yes |
20/311 (6.4) |
291/311 (93.6) |
1.7 (0.9–3.3) |
| Index patient microbiology | |||
| Sample type cultured | |||
| Nonsputum‡ | 3/115 (2.6) | 112/115 (97.4) | Referent |
| Sputum | 34/637 (5.3) | 603/637 (94.7) | 2.1 (0.6–7.0) |
| Acid-fast bacilli stain result | |||
| Negative | 8/239 (3.3) | 231/239 (96.7) | Referent |
| Positive | 29/513 (5.7) | 484/513 (94.3) | 1.7 (0.8–3.8) |
| Acid-fast bacilli culture result | |||
| Negative | 3/72 (4.2) | 69/72 (95.8) | Referent |
| Positive | 34/680 (5.0) | 646/680 (95.0) | 1.2 (0.4–4.0) |
| Isoniazid-susceptible isolate§ | 30/635 (4.7) | 605/635 (95.3) | Referent |
| Isoniazid-resistant isolate§ | 4/45 (8.9) | 41/45 (91.1) | 2.0 (0.7–5.9) |
*Percentages reflect within-row frequencies and might not sum up to 100% because of rounding.
†Values are odds ratios (95% CI) except where indicated.
‡Bronchoalveolar lavages, lung biopsies, and pleural fluid cultures.
§Isoniazid resistance documented only in microbiologically confirmed cases.
Page created: February 19, 2019
Page updated: February 19, 2019
Page reviewed: February 19, 2019
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