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Volume 25, Number 4—April 2019
Research Letter

Peripheral Plasma and Semen Cytokine Response to Zika Virus in Humans

Jean-Michel Mansuy1Comments to Author , Hicham El Costa1, Jordi Gouilly, Catherine Mengelle, Christophe Pasquier, Guillaume Martin-Blondel, Jacques Izopet, and Nabila Jabrane-Ferrat
Author affiliations: Centre Hospitalier Universitaire de Toulouse, Toulouse, France (J.-M. Mansuy, H. El Costa, C. Mengelle, C. Pasquier, G. Martin-Blondel, J. Izopet); INSERM U1043-CNRS UMR5282 Université Toulouse III, Toulouse (H. El Costa, J. Gouilly, G. Martin-Blondel, J. Izopet, N. Jabrane-Ferrat)

Main Article

Figure

Kinetics of Zika virus replication and cytokine secretion in semen, blood, and plasma samples from a Zika virus–infected patient, France, 2016. A) Kinetics of Zika virus RNA detection in whole blood and semen quantified by real-time reverse transcription PCR. B) Quantification of soluble factors in the blood plasma and semen at 4, 11, 35, 82, 139, and 187 days after symptom onset. Dashed lines represent baseline levels of soluble factors quantified in blood plasma and semen obtained from an age-

Figure. Kinetics of Zika virus replication and cytokine secretion in semen, blood, and plasma samples from a Zika virus–infected patient, France, 2016. A) Kinetics of Zika virus RNA detection in whole blood and semen quantified by real-time reverse transcription PCR. B) Quantification of soluble factors in the blood plasma and semen at 4, 11, 35, 82, 139, and 187 days after symptom onset. Dashed lines represent baseline levels of soluble factors quantified in blood plasma and semen obtained from an age-matched healthy donor. CCL, CC-motif chemokine ligand; CXCL, CXC-motif chemokine ligand; G-CSF, granulocyte colony–stimulating factor; IFN-γ, interferon γ; IL, interleukin; MMP, matrix metalloproteinase; sICAM-1, soluble intercellular adhesion molecule 1; VEGF-A, vascular endothelial growth factor A.

Main Article

1These authors contributed equally to this article.

Page created: February 11, 2019
Page updated: February 11, 2019
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