Figure. Kinetics of Zika virus replication and cytokine secretion in semen, blood, and plasma samples from a Zika virus–infected patient, France, 2016. A) Kinetics of Zika virus RNA detection in whole blood and semen quantified by real-time reverse transcription PCR. B) Quantification of soluble factors in the blood plasma and semen at 4, 11, 35, 82, 139, and 187 days after symptom onset. Dashed lines represent baseline levels of soluble factors quantified in blood plasma and semen obtained from an age-matched healthy donor. CCL, CC-motif chemokine ligand; CXCL, CXC-motif chemokine ligand; G-CSF, granulocyte colony–stimulating factor; IFN-γ, interferon γ; IL, interleukin; MMP, matrix metalloproteinase; sICAM-1, soluble intercellular adhesion molecule 1; VEGF-A, vascular endothelial growth factor A.