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Volume 25, Number 4—April 2019

Dispatch

Enterovirus A71 Phenotypes Causing Hand, Foot and Mouth Disease, Vietnam

Hoang Minh Tu VanComments to Author , Nguyen To Anh, Nguyen Thi Thu Hong, Le Nguyen Truc Nhu, Lam Anh Nguyet, Tran Tan Thanh, Nguyen Thi Han Ny, Vu Thi Ty Hang, Truong Huu Khanh, Ho Lu Viet, Do Chau Viet, Ha Manh Tuan, Nguyen Thanh Hung, Du Tuan Quy, Do Quang Ha, Phan Tu Qui, Le Nguyen Thanh Nhan, Guy Thwaites, Nguyen Van Vinh Chau, Louise Thwaites, H. Rogier van Doorn, and Le Van TanComments to Author 
Author affiliations: Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam (H.M.T. Van, N.T. Anh, N.T.T. Hong, L.N.T. Nhu, L.A. Nguyet, T.T. Thanh, N.T.H. Ny, V.T.T. Hang, D.Q. Ha, G. Thwaites, L. Thwaites, H.R. van Doorn, L.V. Tan); Children’s Hospital 2, Ho Chi Minh City (H.M.T. Van, H.L. Viet, D.C. Viet, H.M. Tuan); Children’s Hospital 1, Ho Chi Minh City (T.H. Khanh, N.T. Hung, D.T. Quy, L.N.T. Nhan); University of Oxford, Oxford, UK (P.T. Qui, G. Thwaites, L. Thwaites, H.R. van Doorn); Hospital for Tropical Diseases, Ho Chi Minh City (N.V.V. Chau)

Main Article

Figure 1

Maximum-clade credibility tree illustrating results of phylogeographic analysis of enterovirus A71 subgenogroup B5 coding sequences, Vietnam, July 2013–April 2015. Black circles indicate posterior probabilities ≥70% and state probabilities ≥70% at all nodes. Branch colors represent sampling locations from 5 discrete states in Vietnam (inset map; https://mapchart.net). Small sample sizes from individual provinces precluded phylogeographic analyses at a finer spatial scale. Except for Ho Chi Minh

Figure 1. Maximum-clade credibility tree illustrating results of phylogeographic analysis of enterovirus A71 subgenogroup B5 coding sequences, Vietnam, July 2013–April 2015. Black circles indicate posterior probabilities ≥70% and state probabilities ≥70% at all nodes. Branch colors represent sampling locations from 5 discrete states in Vietnam (inset map; https://mapchart.net). Small sample sizes from individual provinces precluded phylogeographic analyses at a finer spatial scale. Except for Ho Chi Minh City, we grouped provinces in Vietnam from which we sampled viruses into discrete locations, including southeast (Ba Ria, Binh Duong, Binh Phuoc, Dong Nai, Tay Ninh, and Vung Tau Provinces), Mekong Delta (Can Tho, Dong Thap, Hau Giang, Kien Giang, Long An, and Tien Giang Provinces), and Central Highlands (Dac Nong and Lam Dong Provinces). We analyzed whole-genome sequence data using general time reversible plus gamma 4 nt substitution models suggested by IQ-TREE version 1.4.3 (http://www.iqtree.org). Viral protein 1–based analysis yielded similar results (Appendix Figure 2). Enterovirus A71 sequences generated in this study were submitted to GenBank under accession nos. MH_716248–6393 and KP_691643–66.

Main Article

Page created: March 18, 2019
Page updated: March 18, 2019
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