Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 25, Number 4—April 2019
Research

Middle East Respiratory Syndrome Coronavirus Infection Dynamics and Antibody Responses among Clinically Diverse Patients, Saudi Arabia

Hail M. Al-Abdely1, Claire M. Midgley1Comments to Author , Abdulrahim M. Alkhamis, Glen R. Abedi, Xiaoyan Lu, Alison M. Binder, Khalid H. Alanazi, Azaibi Tamin, Weam M. Banjar, Sandra Lester, Osman Abdalla, Rebecca M. Dahl, Mutaz Mohammed, Suvang Trivedi, Homoud S. Algarni, Senthilkumar K. Sakthivel, Abdullah Algwizani, Fahad Bafaqeeh, Abdullah Alzahrani, Ali Abraheem Alsharef, Raafat F. Alhakeem, Hani A. Aziz Jokhdar, Sameeh S. Ghazal, Natalie J. Thornburg, Dean D. Erdman, Abdullah M. Assiri, John T. WatsonComments to Author , and Susan I. Gerber
Author affiliations: Ministry of Health, Riyadh, Saudi Arabia (H.M. Al-Abdely, A.M. Alkhamis, K.H. Alanazi, W.M. Banjar, O. Abdalla, M. Mohammed, H.S. Algarni, A. Alzahrani, A.A. Alsharef, R.F. Alhakeem, H.A.A. Jokhdar, A.M. Assiri); Centers for Disease Control and Prevention, Atlanta, Georgia, USA (C.M. Midgley, G.R. Abedi, X. Lu, A.M. Binder, A. Tamin, S. Lester, R.M. Dahl, S.K. Sakthivel, N.J. Thornburg, D.D. Erdman, J.T. Watson, S.I. Gerber); Princess Nourah Bint Abdulrahman University, Riyadh (W.M. Banjar); Prince Mohammed Bin Abdulaziz Hospital, Riyadh (A. Algwizani, F. Bafaqeeh, S.S. Ghazal)

Main Article

Figure 6

Co-detection of neutralizing serum antibodies with RNA found in serum and the upper and lower respiratory tract among Middle East respiratory syndrome patients, by clinical outcome, Saudi Arabia, August 1, 2015–August 31, 2016. For each patient and specimen, MN titers of serum specimens were compared with estimated viral loads in the same serum specimen (A) or in URT (B) and LRT (C) specimens collected on the same day from the same patient. We defined RNA co-detection as the detection of both RN

Figure 6. Co-detection of neutralizing serum antibodies with RNA found in serum and the upper and lower respiratory tract among Middle East respiratory syndrome patients, by clinical outcome, Saudi Arabia, August 1, 2015–August 31, 2016. For each patient and specimen, MN titers of serum specimens were compared with estimated viral loads in the same serum specimen (A) or in URT (B) and LRT (C) specimens collected on the same day from the same patient. We defined RNA co-detection as the detection of both RNA and neutralizing antibodies (MN) in the same specimen or in respiratory specimens collected on the same day from a given patient. We only included specimens from patients who were known to develop neutralizing antibodies at any point during or after their illness. For the comparison in serum specimens, we only included specimens from patients who were known to have RNA detected in serum, at any point during their illness. For each panel, the number of patients included are indicated above the panel. The number of specimens with RNA co-detection (indicated by X) among those with detectable antibodies (indicated by Y) are also indicated by numbers (X/Y) above each panel. The blue dotted lines indicate the detection cut-offs for each assay. LRT, lower respiratory tract; ND, not detected; MN, microneutralization assay; URT, upper respiratory tract.

Main Article

1These first authors contributed equally to this article.

Page created: March 18, 2019
Page updated: March 18, 2019
Page reviewed: March 18, 2019
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external