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Volume 25, Number 5—May 2019

Outcomes of Bedaquiline Treatment in Patients with Multidrug-Resistant Tuberculosis

Lawrence MbuagbawComments to Author , Lorenzo Guglielmetti, Catherine Hewison, Nyasha Bakare, Mathieu Bastard, Eric Caumes, Mathilde Fréchet-Jachym, Jérôme Robert, Nicolas Veziris, Naira Khachatryan, Tinatin Kotrikadze, Armen Hayrapetyan, Zaza Avaliani, Holger J. Schünemann, and Christian Lienhardt
Author affiliations: St. Joseph’s Healthcare Hamilton, Hamilton, Ontario, Canada (L. Mbuagbaw); Centre for the Development of Best Practices in Health, Yaoundé, Cameroon (L. Mbuagbaw); McMaster University, Hamilton (L. Mbuagbaw, H.J. Schünemann); Centre d'Immunologie et des Maladies Infectieuses, INSERM, Paris (L. Guglielmetti, E. Caumes, J. Robert, N. Veziris); Centre Hospitalier de Bligny, Bris-sous-Forges, France (L. Guglielmetti, M. Fréchet-Jachym); Sorbonne Université, Paris, France (L. Guglielmetti, J. Robert, N. Veziris); Médecins Sans Frontières, Paris (C. Hewison); Janssen Research & Development, LLC, Titusville, New Jersey, USA (N. Bakare); Epicentre, Paris (M. Bastard); Hôpitaux Universitaires de l'Est Parisien, Paris (N. Veziris); Médecins Sans Frontières, Yerevan, Armenia (N. Khachatryan); Médecins Sans Frontières, Tbilisi, Georgia (T. Kotrikadze); National Tuberculosis Control Centre, Yerevan (A. Hayrapetyan); National Centre for Tuberculosis and Lung Disease, Tbilisi (Z. Avaliani); World Health Organization, Geneva, Switzerland (C. Lienhardt); Université de Montpellier, Montpellier, France (C. Lienhardt)

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Table 3

Multivariable analyses for key outcomes in study of bedaquiline treatment for multidrug-resistant tuberculosis

Covariate Culture conversion at 6 mo, n = 318
Success, n = 325
Death, n = 325
Adjusted OR 
(95% CI) p value Adjusted OR (95% CI) p value Adjusted OR (95% CI) p value
Male sex 1.25 (0.65–2.41) 0.499 1.27 (0.74–2.15) 0.382 0.60 (0.24–1.47) 0.264
Age, y 1.01 (0.99–1.04) 0.342 0.99 (0.98–1.01) 0.550 1.05 (1.01–1.09) 0.010
HIV positive 0.42 (0.13–1.39) 0.155 0.35 (0.12–0.99) 0.050 0.97 (0.09–10.05) 0.982
Resistance profile† 0.57 (0.43–0.76) <0.001 0.84 (0.68 −1.04) 0.110 1.14 (0.73–1.79) 0.562
Presence of lung cavitation 0.30 (0.13–0.70) 0.004 0.38 (0.21–0.68) 0.001 5.31 (1.25–22.52) 0.023
Previous use of second-line drugs 0.67 (0.22–2.01) 0.437 0.73 (0.33–1.59) 0.423 1.22 (0.29–5.15) 0.783

*Absence of data on cavitation precluded use of data from South Africa. MDR, multidrug resistant; TB, tuberculosis; XDR, extensively drug resistant.
†Resistance profiles used in this study were MDR TB (reference), MDR TB plus fluoroquinolone, MDR TB plus injectable drugs, and XDR TB.

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Page created: April 18, 2019
Page updated: April 18, 2019
Page reviewed: April 18, 2019
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