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Volume 25, Number 7—July 2019
Synopsis

Carbapenem-Resistant Pseudomonas aeruginosa at US Emerging Infections Program Sites, 2015

Maroya Spalding WaltersComments to Author , Julian E. Grass, Sandra N. Bulens, Emily B. Hancock, Erin C. Phipps, Daniel Muleta, Jackie Mounsey, Marion A. Kainer, Cathleen Concannon, Ghinwa Dumyati, Chris Bower, Jesse Jacob, P. Maureen Cassidy, Zintars Beldavs, Karissa Culbreath, Walter E. Phillips, Dwight J. Hardy, Roberto L. Vargas, Margret Oethinger, Uzma Ansari, Richard Stanton, Valerie Albrecht, Alison Laufer Halpin, Maria Karlsson, J. Kamile Rasheed, and Alexander Kallen
Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA (M.S. Walters, J.E. Grass, S.N. Bulens, U. Ansari, R. Stanton, V. Albrecht, A.L. Halpin, M. Karlsson, J.K. Rasheed, A. Kallen); New Mexico Emerging Infections Program, Santa Fe, New Mexico, USA (E.B. Hancock, E.C. Phipps); University of New Mexico, Albuquerque, New Mexico, USA (E.B. Hancock, E.C. Phipps, K. Culbreath); Tennessee Department of Public Health, Nashville, Tennessee, USA (D. Muleta, J. Mounsey, M.A. Kainer); University of Rochester, Rochester, New York, USA (C. Concannon, G. Dumyati, D.J. Hardy); Atlanta Veterans Affairs Medical Center, Decatur, Georgia, USA (C. Bower); Atlanta Research and Education Foundation, Decatur (C. Bower); Georgia Emerging Infections Program, Atlanta (C. Bower, J. Jacob); Emory University School of Medicine, Atlanta (J. Jacob); Oregon Health Authority, Portland, Oregon, USA (P.M. Cassidy, Z. Beldavs); TriCore Reference Laboratories, Albuquerque (K. Culbreath); Tristar Centennial Medical Center, Nashville (W.E. Phillips, Jr.); Rochester Regional Health, Rochester (R.L. Vargas); Providence Health and Services, Renton, Washington, USA (M. Oethinger)

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Table 5

Characteristics of carbapenemase-producing isolates of carbapenem-resistant Pseudomonas aeruginosa from incident cases, United States, July–October 2015

Isolate no. Site Carbapenemase Carbapenemase gene location ST Antimicrobial resistance pattern*
1 New Mexico IMP-18 Plasmid ST179 AMK, CAZ, CAZ/AVI, CIP, DOR, FEP, GEN, IMI, LEV, MER, CEF/TAZ, TOB
2 New Mexico VIM-2 Chromosomal ST308 CAZ,† CAZ/AVI, CIP, DOR, GEN, IMI, LEV, MER, CEF/TAZ, TOB
3 Tennessee HMB-2 Chromosomal ST235 AMK, CAZ, CAZ/AVI, CIP, DOR, FEP, GEN, LEV, MER, PIP/TAZ, CEF/TAZ, TOB

*Resistance pattern based on reference broth microdilution testing using 2019 Clinical and Laboratory Standards Institute interpretative criteria. AMK, amikacin; CAZ, ceftazidime; CAZ/AVI, ceftazidime/avibactam; CEF/TAZ, ceftolozane-tazobactam; CIP, ciprofloxacin; DOR, doripenem; FEP, cefepime; GEN, gentamicin; HMB, Hamburg metallo-β-lactamase; IMI, imipenem; IMP, active-on-imipenem; LEV, levofloxacin; MER, meropenem; PIP/TAZ, piperacillin/tazobactam; ST, sequence type; TOB, tobramycin; VIM, Verona integron mediated.
†Intermediate antimicrobial susceptibility.

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Page created: June 17, 2019
Page updated: June 17, 2019
Page reviewed: June 17, 2019
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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