Added Value of Comprehensive Program to Provide Universal Access to Care for Sputum Smear–Negative Drug-Resistant Tuberculosis, China
Fei Huang, Susan van den Hof, Yan Qu, You Li, Hui Zhang

, Lixia Wang, Miaomiao Sun, Wei Lu, Shuangyi Hou, Tianhua Zhang, Shitong Huan, Daniel P. Chin, and Frank Cobelens
Author affiliations: Chinese Center for Disease Control and Prevention, Beijing, China (F. Huang, Y. Qu, Y. Li, H. Zhang, L. Wang); The Royal Netherlands Tuberculosis Foundation, The Hague, the Netherlands (S. van den Hof); Academic Medical Center, Amsterdam, the Netherlands (S. van den Hof, F. Cobelens); PATH, Beijing (M. Sun); Jiangsu Provincial Center for Disease Control and Prevention, Jiangsu, China (W. Lu); Hubei Provincial Center for Disease Control and Prevention, Hubei, China (S. Hou); Shaanxi Provincial Institute for Tuberculosis Control and Prevention, Shaanxi, China (T. Zhang); Bill & Melinda Gates Foundation, Beijing (S. Huan); Bill & Melinda Gates Foundation, Seattle, Washington, USA (D.P. Chin)
Main Article
Table 1
Diagnostic algorithm used during baseline and intervention period in study of added value of comprehensive program to provide universal access to care for sputum smear–negative drug-resistant TB, China*
Level |
Baseline |
Intervention |
County
|
Light microscopy (Ziehl–Neelsen staining), smear examination, and chest radiograph for all presumptive TB patients
|
LED fluorescence microscopy (auramine staining), smear examination, and chest radiograph for all presumptive TB patients; culture for all patients with a diagnosis of smear-negative TB
|
City |
Culture and phenotypic DST only for patients at
high risk for MDR TB; culture for smear-positive patients in Zhenjiang |
Line-probe assay (Genechip; CapitaBio, http://www.capitalbiotech.com) used in Yichang; GenoType
(Hain Lifesciences, https://www.hain-lifescience.de/ en/company/contact.html) used in Zhenjiang for all bacteriologically confirmed pulmonary TB |
Main Article
Page created: June 17, 2019
Page updated: June 17, 2019
Page reviewed: June 17, 2019
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