Volume 25, Number 7—July 2019
Synopsis
Added Value of Comprehensive Program to Provide Universal Access to Care for Sputum Smear–Negative Drug-Resistant Tuberculosis, China
Fei Huang, Susan van den Hof, Yan Qu, You Li, Hui Zhang
, Lixia Wang, Miaomiao Sun, Wei Lu, Shuangyi Hou, Tianhua Zhang, Shitong Huan, Daniel P. Chin, and Frank Cobelens
, Lixia Wang, Miaomiao Sun, Wei Lu, Shuangyi Hou, Tianhua Zhang, Shitong Huan, Daniel P. Chin, and Frank Cobelens
Table 2
Drug resistance testing and results by prefecture and smear status in study of comprehensive program to provide universal access to care for sputum smear–negative drug-resistant tuberculosis, China*
| Characteristic | Yichang, no. (%) |
Zhenjiang, no. (%) |
|||
|---|---|---|---|---|---|
| Baseline | Intervention | Baseline | Intervention | ||
| Smear-positive patients | |||||
| Patients given a diagnosis | 1,177 (100) | 949 (100) | 631 (100) | 560 (100) | |
| Patients tested for drug resistance | 36 (3.1) | 863 (90.9) | 470 (74.5) | 518 (92.5) | |
| Rapid resistance result available | 36 (3.1) | 828 (87.2) | 453 (71.8) | 457 (81.6) | |
| Drug resistance test result | |||||
| No resistance to rifampin and isoniazid | 24 (2.0) | 715 (75.3) | 405 (64.2) | 389 (69.5) | |
| Resistance to only isoniazid | 3 (0.3) | 46 (4.8) | 26 (4.1) | 38 (6.8) | |
| Any rifampin resistance | 9 (0.8) | 67 (7.1) | 21 (3.3) | 30 (5.4) | |
| MDR TB | 6 (0.5) | 30 (3.2) | 14 (2.2) | 18 (3.2) | |
| Resistance to only rifampin |
3 (0.3) |
37 (3.9) |
7 (1.1) |
12 (2.1) |
|
| Smear-negative patients | |||||
| Patients given a diagnosis | 2,258 (100) | 2,055 (100) | 1,156 (100) | 800 (100) | |
| Cultures performed | 14 (0.6) | 1,842 (89.6) | 19 (1.6) | 749 (93.6) | |
| Cultures positive | 12 (0.5) | 358 (17.4) | 19 (1.6) | 52 (6.5) | |
| Patients tested for drug resistance† | 1 (<0.1) | 352 (17.1) | 22 (1.9) | 53 (6.6) | |
| Rapid resistance result available | 1 (<0.1) | 330 (16.1) | 21 (1.8) | 47 (5.9) | |
| Drug resistance test result | |||||
| No resistance to rifampin and isoniazid | 0 | 299 (14.5) | 19 (1.6) | 43 (5.4) | |
| Resistance to only isoniazid | 1 (<0.1) | 19 (0.9) | 0 | 3 (0.4) | |
| Any rifampin resistance‡ | 0 | 12 (0.6) | 2 (0.2) | 1 (0.1) | |
| MDR TB | 0 | 10 (0.5) | 2 (0.2) | 1 (0.1) | |
| Resistance to only rifampin | 0 | 2 (0.1) | 0 | 0 | |
*Differences in numbers of patients tested and numbers with a test result reflect indeterminate test results. MDR TB, multidrug-resistant tuberculosis (i.e., resistant to rifampin and isoniazid); TB, tuberculosis.
†Including 10 smear-negative patients who had no culture results and 24 smear-negative culture-negative patients for whom a line-probe assay was performed directly for sputum.
‡Including 2 smear-negative patients for whom a line-probe assay was performed directly for sputum.
Page created: June 17, 2019
Page updated: June 17, 2019
Page reviewed: June 17, 2019
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