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Volume 25, Number 9—September 2019
Research

Effect of Pneumococcal Conjugate Vaccines on Pneumococcal Meningitis, England and Wales, July 1, 2000–June 30, 2016

Godwin Oligbu, Sarah Collins, Abdelmajid Djennad, Carmen L. Sheppard, Norman K. Fry, Nick J. Andrews, Ray Borrow, Mary E. Ramsay, and Shamez N. LadhaniComments to Author 
Author affiliations: Public Health England, London, UK (G. Oligbu, S. Collins, A. Djennad, C.L. Sheppard, N.K. Fry, N.J. Andrews, M.E. Ramsay, S.N. Ladhani); St. George's, University of London, London (G. Oligbu, S.N. Ladhani); Public Health England Manchester Royal Infirmary, Manchester, UK (R. Borrow)

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Figure 1

Corrected trends in incidence of pneumococcal meningitis and nonmeningitis cases by Streptococcus pneumoniae serotype, age group, and epidemiologic year, England and Wales, July 1, 2000–June 30, 2016. A–H) Meningitis (A, C, E, G) and nonmeningitis (B, D, F, H) cases in patients <5 years of age (A, B); patients 5–64 years of age (C, D); patients >65 years of age (E, F); and patients of all ages (G, H). The raw numbers of cases for each year were corrected for missing serotype and age with t

Figure 1. Corrected trends in incidence of pneumococcal meningitis and nonmeningitis cases by Streptococcus pneumoniae serotype, age group, and epidemiologic year, England and Wales, July 1, 2000–June 30, 2016. A–H) Meningitis (A, C, E, G) and nonmeningitis (B, D, F, H) cases in patients <5 years of age (A, B); patients 5–64 years of age (C, D); patients >65 years of age (E, F); and patients of all ages (G, H). The raw numbers of cases for each year were corrected for missing serotype and age with the assumption that cases with missing data for age, serotype, or both had the same age and serotype distribution as those cases for which this information was known; cases were also corrected for annual changes in population denominators in each age group (13).The vertical lines denote the introduction of PCV7 and PCV13 into the national childhood immunization program. PCV7 refers to serotypes 4, 6B, 9V, 14, 18C, 19F, and 23F, and additional PCV13 refers to serotypes 1, 3, 5, 6A, 7F, and 19A. Non-PCV13 refers to all other serotypes. PCV7, 7-valent pneumococcal conjugate vaccine; PCV13, 13-valent pneumococcal conjugate vaccine.

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Page created: August 20, 2019
Page updated: August 20, 2019
Page reviewed: August 20, 2019
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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