Godwin Oligbu, Sarah Collins, Abdelmajid Djennad, Carmen L. Sheppard, Norman K. Fry, Nick J. Andrews, Ray Borrow, Mary E. Ramsay, and Shamez N. Ladhani
Figure 2. Mean annual number of pneumococcal meningitis cases among patients of all ages by Streptococcus pneumoniae serotype and period, England and Wales, July 1, 2000–June 30, 2016. The pre-PCV7 period refers to July 1, 2000–June 30, 2006, pre-PCV13 period July 1, 2008–June 30, 2010, and PCV13 period July 1, 2011–June 30, 2016. PCV7, 7-valent pneumococcal conjugate vaccine; PCV13, 13-valent pneumococcal conjugate vaccine. For cases diagnosed during the PCV13 period (July 1, 2011–June 30, 2016), we used multivariable logistic regression to calculate the odds of meningitis vs. nonmeningitis. O, other serotypes.