Volume 25, Number 9—September 2019
CME ACTIVITY - Synopsis
Classification of Trauma-Associated Invasive Fungal Infections to Support Wound Treatment Decisions
Table 2
Characteristics of US military patients with IFI after battlefield trauma in Afghanistan, June 1, 2009–December 31, 2014*
Characteristic | IFI |
p value | ||
---|---|---|---|---|
Proven, n = 40 | Probable, n = 30 | Possible, n = 24 | ||
Blast injury | 40 (100) | 29 (96.7) | 23 (95.8) | 0.327 |
Injured while on foot patrol† |
29 (100) |
26 (96.3) |
18 (85.7) |
0.062 |
Injury severity score | ||||
Median (IQR) | 42 (33–57) | 40 (33–50) | 35 (30–44) | 0.127 |
>26/critical |
39 (97.5) |
27 (90.0) |
21 (87.5) |
0.279 |
Blood units received 24 h after injury‡ | ||||
Median (IQR) | 31 (23–43) | 34 (23–47) | 27 (17–37) | 0.276 |
10–20 units | 6 (15.0) | 4 (13.3) | 8 (34.8) | 0.121 |
>20 units |
33 (82.5) |
24 (80.0) |
14 (60.9) |
0.074 |
Traumatic amputation§ |
30 (75.0) |
20 (66.7) |
14 (58.3) |
0.376 |
SOFA score, median (IQR) | ||||
Germany | 11 (8–15) | 10.5 (7–12) | 11 (5–12) | 0.413 |
US hospital |
9 (5–13) |
7.5 (1–11) |
4.5 (1–7.5) |
0.007 |
Duration of antifungal use, median (IQR) |
36 (23–49) |
24 (18–36) |
16 (0–24) |
<0.001 |
Outcome | ||||
Surgical amputations¶ | 27 (67.5) | 13 (43.3) | 10 (41.7) | 0.057 |
Death | 7 (17.5) | 1 (3.3) | 0 | 0.030 |
*Values are no. (%) except as indicated. IFI, invasive fungal wound infections; IQR, interquartile range; SOFA, sequential organ failure assessment.
†Status of whether patient was on foot patrol or in a vehicle is missing for 17 IFI patients (11 Proven, 3 Probable, and 3 Possible). Percentages and p-values based on total minus missing.
‡Blood information is missing for 1 patient with a possible IFI. Percentages and p-values based on total minus missing.
§Includes amputations that occurred before admission to a US hospital.
¶Defined as amputations that occurred after admission to a US hospital.