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Volume 25, Number 9—September 2019
Dispatch

Vaccine Effectiveness against DS-1–Like Rotavirus Strains in Infants with Acute Gastroenteritis, Malawi, 2013–2015

Khuzwayo C. JereComments to Author , Naor Bar-Zeev, Adams Chande, Aisleen Bennett, Louisa Pollock, Pedro F. Sanchez-Lopez, Osamu Nakagomi, Jacqueline E. Tate, Umesh D. Parashar, Robert S. Heyderman, Neil French, Miren Iturriza-Gomara1, and Nigel A. Cunliffe1
Author affiliations: University of Malawi, Blantyre, Malawi (K.C. Jere); Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre (K.C. Jere, N. Bar-Zeev, A. Chande, A. Bennett, L. Pollock, R.S. Heyderman, N. French, M. Iturriza-Gomara); University of Liverpool, Liverpool, UK (K.C. Jere, N. Bar-Zeev, A. Bennett, L. Pollock, N. French, M. Iturriza-Gomara, N.A. Cunliffe); Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA (N. Bar-Zeev); University of Murcia, Murcia, Spain (P.F. Sanchez-Lopez); Nagasaki University, Nagasaki, Japan (O. Nakagomi, J.E. Tate); Centers for Disease Control and Prevention, Atlanta, Georgia, USA (U.D. Parashar); University College London, London, UK (R.S. Heyderman)

Main Article

Table

Point estimates of vaccine effectiveness by rotavirus genotype constellation based on the complete genetic composition of rotavirus strains, Blantyre, Malawi*

Rotavirus strain type Sequenced strains from test-positive case-patients†
 Rotavirus test-negative controls
 Adjusted logistic regression for year of presentation
No. tested positive No. known vaccine status No. (%) 2-dose vaccine No. controls No. known vaccine status No. (%) 2-dose vaccine Rotarix vaccine effectiveness, % (95% CI) p value
DS-1–like G1P[8] 13 13 10 (76.9) 426 410 365 (89) 85.6 (34.4–96.8) 0.01
DS-1–like G2 30 28 24 (85.7) 481 465 411 (88.4) 48.5 (−154.3 to 89.6) 0.42
Wa-like G1 38 38 34 (89.5) 440 424 376 (88.7) 76.7 (−153.8 to 97.9) 0.23

*Rotavirus strains detected at Queen Elisabeth Central Hospital during January 2013–December 2015. Case-patients were fully vaccinated infants <12 mo of age.
†Complete whole-genome sequences were generated.

Main Article

1These authors contributed equally to this article.

Page created: August 21, 2019
Page updated: August 21, 2019
Page reviewed: August 21, 2019
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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