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Volume 25, Number 9—September 2019
Research

Clonality of Fluconazole-Nonsusceptible Candida tropicalis in Bloodstream Infections, Taiwan, 2011–2017

Pao-Yu Chen, Yu-Chung Chuang, Un-In Wu, Hsin-Yun Sun, Jann-Tay Wang, Wang-Huei Sheng, Hsiu-Jung Lo, Hurng-Yi Wang, Yee-Chun ChenComments to Author , and Shan-Chwen Chang
Author affiliations: National Taiwan University Hospital, Taipei, Taiwan (P.-Y. Chen, Y.-C. Chuang, U.-I. Wu, H.-Y. Sun, J.-T. Wang, W.-H. Sheng, Y.-C. Chen, S.-C. Chang); National Taiwan University College of Medicine, Taipei (P.-Y. Chen, H.-Y. Wang, Y.-C. Chen, S.-C. Chang); National Health Research Institutes, Miaoli, Taiwan (J.-T. Wang, H.-J. Lo, Y.-C. Chen)

Main Article

Figure 2

Minimum spanning tree of 350 C. tropicalis isolates from multilocus sequence typing (MLST) data. A) Minimum spanning tree of 165 C. tropicalis blood isolates from this study’s cohort (Taiwan, 2011–2017) and 185 isolates with fluconazole nonsusceptibility from the central C. tropicalis MLST global database (https://pubmlst.org/ctropicalis). Each circle corresponds to a diploid sequence type (DST). The size of the circle indicates the number of the isolates belonging to a specific DST and classifi

Figure 2. Minimum spanning tree of 350 C. tropicalis isolates from multilocus sequence typing (MLST) data. A) Minimum spanning tree of 165 C. tropicalis blood isolates from this study’s cohort (Taiwan, 2011–2017) and 185 isolates with fluconazole nonsusceptibility from the central C. tropicalis MLST global database (https://pubmlst.org/ctropicalis). Each circle corresponds to a diploid sequence type (DST). The size of the circle indicates the number of the isolates belonging to a specific DST and classified as fluconazole resistant (red), susceptible-dose-dependent (yellow), or susceptible (white). Lines between circles indicate the similarity between profiles: bold lines indicate 5 of 6 alleles are identical, solid lines indicate 4 alleles are identical, and dotted lines indicate ≤3 alleles are similar. Shaded areas indicate groups of target clonal complexes (CCs). B) Enlarged area of CC10 and CC11 (purple shading). C) Enlarged area of fluconazole nonsusceptible CC3 (green shading). D) Enlarged area of fluconazole susceptible CC3 (pink shading).

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Page updated: August 21, 2019
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