Hypervirulent Klebsiella pneumoniae as Unexpected Cause of Fatal Outbreak in Captive Marmosets, Brazil
Juliana Mariotti Guerra, Natália Coelho Couto de A. Fernandes, Alessandra Loureiro Morales dos Santos, Joana de Souza Pereira Barrel, Bruno Simões Sergio Petri, Liliane Milanelo, Monique Ribeiro Tiba-Casas, Alcina Maria Liserre, Cláudia Regina Gonçalves, Cláudio Tavares Sacchi, José Luiz Catão-Dias, and Carlos Henrique Camargo
Author affiliations: Instituto Adolfo Lutz, São Paulo, Brazil (J.M. Guerra, N.C.C.A. Fernandes, A.L.M. dos Santos, J.S.P. Barrel, M.R. Tiba-Casas, A.M. Liserre, C.R Gonçalves., C.T Sacchi., C.H. Camargo); Universidade de São Paulo, São Paulo (N.C.C.A. Fernandes, A.L.M. dos Santos, J.L. Catão-Dias); Parque Ecológico do Tietê, São Paulo (B.S.S. Petri, L. Milanelo)
Figure 1. Microscopic findings of histological and histochemical examination of tissue samples from captive marmosets in investigation of a fatal epizootic caused by highly virulent Klebsiella pneumoniae sequence type 86 strain P04 in Brazil, 2019. A) Spleen shows necrosis in germinal centers, suppurative splenitis, and hemorrhage (inset: necrosis in germinal center). Hematoxylin and eosin stain (H&E); original magnification ×4. B) Brain (meninges) shows bacterial rods inside vascular lumen (arrow). H&E stain; original magnification ×40. C) Lung shows sinterstitial pneumonia (H&E stain; original magnification ×4) and alveolar hemorrhage (inset; H&E stain; original magnification ×10). D–F) Liver samples. D) Numerous intravascular bacilli (arrow). H&E stain; original magnification ×100. E) Hepatocellular necrosis (arrowheads) associated with numerous bacterial rods (arrow) and neutrophils in the sinusoids. H&E stain; original magnification ×40. F) Sinusoids filled with gram-negative bacterial structures (arrow) and neutrophils. Gram stain; original magnification ×1,000.
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