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Volume 26, Number 12—December 2020
Dispatch

Characterization and Source Investigation of Multidrug-Resistant Salmonella Anatum from a Sustained Outbreak, Taiwan

Ye Feng, Yi-Jung Chang, Shih-Chuan Pan, Lin-Hui Su, Hsin-Chieh Li, Hsin-Ping Yang, Min-Jia Yu, and Cheng-Hsun ChiuComments to Author 
Author affiliations: Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China (Y. Feng); Institute for Translational Medicine, Zhejiang University School of Medicine, Hangzhou (Y. Feng); Key Laboratory of Microbial Technology and Bioinformatics of Zhejiang Province, Hangzhou (Y. Feng); Division of Pediatric Infectious Diseases, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan (Y.-J. Chang, S.-C. Pan, C.-H. Chiu); Molecular Infectious Disease Research Center, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan (Y.-J. Chang, L.-H. Su, H.-C. Li, H.-P. Yang, M.-J. Yu, C.-H. Chiu)

Main Article

Figure 2

Genomic analysis of the outbreak caused by Salmonella enterica serotype Anatum, Taiwan. A) Dated phylogeny for Salmonella Anatum clinical isolates and food and environmental isolates. All isolates were divided into 3 clades, shown at right. The nodes’ colors represent the geo source; nodes with black rings were from meat or the environment, and the remainder were derived from the patients. The right heatmap represents the presence (in black) or absence (in gray) of key antimicrobial-resistance g

Figure 2. Genomic analysis of the outbreak caused by Salmonella enterica serotype Anatum, Taiwan. A) Dated phylogeny for Salmonella Anatum clinical isolates and food and environmental isolates. All isolates were divided into 3 clades, shown at right. The nodes’ colors represent the geo source; nodes with black rings were from meat or the environment, and the remainder were derived from the patients. The right heatmap represents the presence (in black) or absence (in gray) of key antimicrobial-resistance genes (1, blaDHA-1; 2, qnrB4; 3, blaCMY-2). B) Minimal spanning tree based on alleles identified through core genome multilocus sequence typing. Dots with black circles represent food isolates; the others are clinical isolates. The collection date for the 6 US isolates in panel B was missing in GenBank and therefore not included in panel A. Scale bar indicates 5 single nucleotide polymorphisms. C) Gene structure of multidrug-resistant plasmids in Salmonella Anatum in Taiwan compared with international isolates. Two types of plasmids were identified in the clade I S. Anatum isolates in Taiwan. One carried blaCMY-2, with its structure being shown by pSal-5091_CMY. A similar plasmid, pCMY2 (GenBank accession no. LC019731.1), is shown. The other carried blaDHA-1; its structure is shown by pSal-5091_DHA. International isolates shown in the figure, whose genomes also were downloaded from GenBank (Appendix), possess very similar plasmids. In certain isolates, the 2 plasmids can integrate into 1 large plasmid, with its structure shown by pSal-3973_DHA_CMY. Red genes represent antimicrobial-resistance genes; blue genes represent transposase/integrase genes; and yellow genes represent Inc-determinant genes.

Main Article

Page created: August 06, 2020
Page updated: August 18, 2020
Page reviewed: August 18, 2020
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