Volume 26, Number 5—May 2020
CME ACTIVITY - Synopsis
Food Safety and Invasive Cronobacter Infections during Early Infancy, 1961–2018
Table 3
Sample type | Sample type tested | Sample yielded Cronobacter | Sample isolate indistinguishable from clinical isolate† |
---|---|---|---|
PIF from opened containers | 46/52 (87) | 10/46 (22)‡ | 6/7 (86) |
Breast pump collection kit/pump-expressed breastmilk | 5/52 (9) | 2/5 (40) | 1/2(50) |
Water from opened bottle | 16/52 (27) | 2/16 (13) | 1/1 (100) |
Environmental surfaces | 17/52 (31) | 6/17 (35)§ | 4/6 (67) |
*Values are no. positive/no. tested (%). Results from first source investigation in the United States was reported in 1989 (8).
†Comparison made using pulsed-field gel electrophoresis.
‡Cronobacter contamination was identified in powdered infant formula during investigations conducted during 1989–2017.
§Of 6 cases that yielded an isolate from an environmental surface, 4 were from kitchen sink surfaces, 1 from a pacifier, and 1 from a bottle nipple.
References
- Bowen AB, Braden CR. Invasive Enterobacter sakazakii disease in infants. Emerg Infect Dis. 2006;12:1185–9. DOIPubMedGoogle Scholar
- Urmenyi AM, Franklin AW. Neonatal death from pigmented coliform infection. Lancet. 1961;1:313–5. DOIPubMedGoogle Scholar
- Muytjens HL, Zanen HC, Sonderkamp HJ, Kollée LA, Wachsmuth IK, Farmer JJ III. Analysis of eight cases of neonatal meningitis and sepsis due to Enterobacter sakazakii. J Clin Microbiol. 1983;18:115–20. DOIPubMedGoogle Scholar
- van Acker J, de Smet F, Muyldermans G, Bougatef A, Naessens A, Lauwers S. Outbreak of necrotizing enterocolitis associated with Enterobacter sakazakii in powdered milk formula. J Clin Microbiol. 2001;39:293–7. DOIPubMedGoogle Scholar
- Patrick ME, Mahon BE, Greene SA, Rounds J, Cronquist A, Wymore K, et al. Incidence of Cronobacter spp. infections, United States, 2003-2009. Emerg Infect Dis. 2014;20:1520–3. DOIPubMedGoogle Scholar
- Food and Agriculture Organization of the United Nations, World Health Organization. Enterobacter sakazakii (Cronobacter spp.) in powdered follow-up formulae: meeting report. 2008 [cited 2019 Feb 14]. https://www.who.int/foodsafety/publications/micro/MRA_followup.pdf
- Forsythe SJ. Updates on the Cronobacter genus. Annu Rev Food Sci Technol. 2018;9:23–44. DOIPubMedGoogle Scholar
- Simmons BP, Gelfand MS, Haas M, Metts L, Ferguson J. Enterobacter sakazakii infections in neonates associated with intrinsic contamination of a powdered infant formula. Infect Control Hosp Epidemiol. 1989;10:398–401. DOIPubMedGoogle Scholar
- Biering G, Karlsson S, Clark NC, Jónsdóttir KE, Lúdvígsson P, Steingrímsson O. Three cases of neonatal meningitis caused by Enterobacter sakazakii in powdered milk. J Clin Microbiol. 1989;27:2054–6. DOIPubMedGoogle Scholar
- Noriega FR, Kotloff KL, Martin MA, Schwalbe RS. Nosocomial bacteremia caused by Enterobacter sakazakiki and Leuconostoc mesenteroides resulting from extrinsic contamination of infant formula. Pediatr Infect Dis J. 1990;9:447–9. DOIPubMedGoogle Scholar
- Centers for Disease Control and Prevention. From the Centers for Disease Control and Prevention. Enterobacter sakazakii infections associated with the use of powdered infant formula—Tennessee, 2001. JAMA. 2002;287:2204–5.PubMedGoogle Scholar
- Jason J. Prevention of invasive Cronobacter infections in young infants fed powdered infant formulas. Pediatrics. 2012;130:e1076–84. DOIPubMedGoogle Scholar
- United States Food and Drug Administration Enforcement Story Archives. Center for Food Safety and Applied Nutrition. 2002 [cited 2019 Feb 14]. https://www.fda.gov/iceci/enforcementactions/enforcementstory/enforcementstoryarchive/ucm105959.htm
- Food and Agriculture Organization of the United Nations, World Health Organization. Safe preparation, storage and handling of powdered infant formula: guidelines. 2007 [cited 2019 Feb 14]. http://www.who.int/foodsafety/publications/micro/PIF_Bottle_en.pdf
- United States Food and Drug Administration. FDA takes final step on infant formula protections. 2014 Jun 9 [cited 2019 Feb 14]. https://www.fda.gov/ForConsumers/ConsumerUpdates/ucm048694.htm
- Bowen A, Wiesenfeld HC, Kloesz JL, Pasculle AW, Nowalk AJ, Brink L, et al. Notes from the field: Cronobacter sakazakii infection associated with feeding extrinsically contaminated expressed human milk to a premature infant—Pennsylvania, 2016. MMWR Morb Mortal Wkly Rep. 2017;66:761–2. DOIPubMedGoogle Scholar
- McMullan R, Menon V, Beukers AG, Jensen SO, van Hal SJ, Davis R. Cronobacter sakazakii infection from expressed breast milk, Australia. Emerg Infect Dis. 2018;24:393–4. DOIPubMedGoogle Scholar
- Sundararajan M, Enane LA, Kidwell LA, Gentry R, Danao S, Bhumbra S, et al. Notes from the field: Cronobacter sakazakii meningitis in a full-term neonate fed exclusively with breast milk—Indiana, 2018. MMWR Morb Mortal Wkly Rep. 2018;67:1248–9. DOIPubMedGoogle Scholar
- PubMLST: public databases for molecular typing and microbial genome diversity [cited 2019 Feb 14]. https://pubmlst.org
- Chaves CEV, Brandão MLL, Lacerda MLGG, Rocha CABC, Leone de Oliveira SMDV, Parpinelli TC, et al. Fatal Cronobacter sakazakii sequence type 494 meningitis in a newborn, Brazil. Emerg Infect Dis. 2018;24:1948–50. DOIPubMedGoogle Scholar
- Muytjens HL, Zanen HC, Sonderkamp HJ, Kollée LA, Wachsmuth IK, Farmer JJ III. Analysis of eight cases of neonatal meningitis and sepsis due to Enterobacter sakazakii. J Clin Microbiol. 1983;18:115–20. DOIPubMedGoogle Scholar
- Block C, Peleg O, Minster N, Bar-Oz B, Simhon A, Arad I, et al. Cluster of neonatal infections in Jerusalem due to unusual biochemical variant of Enterobacter sakazakii. Eur J Clin Microbiol Infect Dis. 2002;21:613–6. DOIPubMedGoogle Scholar
- Teramoto S, Tanabe Y, Okano E, Nagashima T, Kobayashi M, Etoh Y. A first fatal neonatal case of Enterobacter sakazakii infection in Japan. Pediatr Int. 2010;52:312–3. DOIPubMedGoogle Scholar
- Drudy D, Mullane NR, Quinn T, Wall PG, Fanning S. Enterobacter sakazakii: an emerging pathogen in powdered infant formula. Clin Infect Dis. 2006;42:996–1002. DOIPubMedGoogle Scholar
- Coignard B, Vaillant V, Vincent JP, Lefleche A, Mariani-Kurkdjian P, Bernet C, et al.. Severe infections of Enterobacter sakazakii in neonates who consumed powdered infant formula, France, October–December 2004 [in French]. Bulletin Epidemiologique Hebdomadaire. 2006;2–3:10–3.
- Farmer JJ III. My 40-year history with Cronobacter/Enterobacter sakazakii—lessons learned, myths debunked, and recommendations. Front Pediatr. 2015;3:84. DOIPubMedGoogle Scholar
- Jongenburger I, Reij MW, Boer EP, Gorris LG, Zwietering MH. Actual distribution of Cronobacter spp. in industrial batches of powdered infant formula and consequences for performance of sampling strategies. Int J Food Microbiol. 2011;151:62–9. DOIPubMedGoogle Scholar
- Jaradat ZW, Al Mousa W, Elbetieha A, Al Nabulsi A, Tall BD. Cronobacter spp.—opportunistic food-borne pathogens. A review of their virulence and environmental-adaptive traits. J Med Microbiol. 2014;63:1023–37. DOIPubMedGoogle Scholar
- Jones G, Pardos de la Gandara M, Herrera-Leon L, Herrera-Leon S, Varela Martinez C, Hureaux-Roy R, et al. Outbreak of Salmonella enterica serotype Poona in infants linked to persistent Salmonella contamination in an infant formula manufacturing facility, France, August 2018 to February 2019. Euro Surveill. 2019;24. DOIPubMedGoogle Scholar
- Rodriguez-Urrego J, Herrera-Leon S, Echeita-Sarriondia A, Soler P, Simon F, Mateo S; Investigation team. Nationwide outbreak of Salmonella serotype Kedougou associated with infant formula, Spain, 2008. Euro Surveill. 2010;15:19582.PubMedGoogle Scholar
- Earnest GS, Reed LD, Conover D, Estill C, Gjessing C, Gressel M, et al.; Centers for Disease Control and Prevention. Engineering and public health at CDC. MMWR Suppl. 2006;55:10–3.PubMedGoogle Scholar
- Appleton J, Laws R, Russell CG, Fowler C, Campbell KJ, Denney-Wilson E. Infant formula feeding practices and the role of advice and support: an exploratory qualitative study. BMC Pediatr. 2018;18:12. DOIPubMedGoogle Scholar
- Losio MN, Pavoni E, Finazzi G, Agostoni C, Daminelli P, Dalzini E, et al. Preparation of powdered infant formula: could product’s safety be improved? J Pediatr Gastroenterol Nutr. 2018;67:543–6. DOIPubMedGoogle Scholar
- Iversen C, Mullane N, McCardell B, Tall BD, Lehner A, Fanning S, et al. Cronobacter gen. nov., a new genus to accommodate the biogroups of Enterobacter sakazakii, and proposal of Cronobacter sakazakii gen. nov., comb. nov., Cronobacter malonaticus sp. nov., Cronobacter turicensis sp. nov., Cronobacter muytjensii sp. nov., Cronobacter dublinensis sp. nov., Cronobacter genomospecies 1, and of three subspecies, Cronobacter dublinensis subsp. dublinensis subsp. nov., Cronobacter dublinensis subsp. lausannensis subsp. nov. and Cronobacter dublinensis subsp. lactaridi subsp. nov. Int J Syst Evol Microbiol. 2008;58:1442–7. DOIPubMedGoogle Scholar
- Alsonosi A, Hariri S, Kajsík M, Oriešková M, Hanulík V, Röderová M, et al. The speciation and genotyping of Cronobacter isolates from hospitalised patients. Eur J Clin Microbiol Infect Dis. 2015;34:1979–88. DOIPubMedGoogle Scholar
Page created: April 15, 2020
Page updated: April 15, 2020
Page reviewed: April 15, 2020
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.