Volume 26, Number 5—May 2020
Dispatch
A Neighbor-Based Approach to Identify Tuberculosis Exposure, the Kopanyo Study
Patrick K. Moonan
, Nicola M. Zetola, James L. Tobias, Joyce Basotli, Rosanna Boyd, Eleanor S. Click, Mbatshi Dima, Othusitse Fane, Alyssa M. Finlay, Matsiri Ogopotse, Xiao J. Wen, Chawangwa Modongo, and John E. Oeltmann
, Nicola M. Zetola, James L. Tobias, Joyce Basotli, Rosanna Boyd, Eleanor S. Click, Mbatshi Dima, Othusitse Fane, Alyssa M. Finlay, Matsiri Ogopotse, Xiao J. Wen, Chawangwa Modongo, and John E. Oeltmann
Table
Number of index patients and possible additional subsequent contacts and future-related patients identified by using a nearest-neighbor approach to tuberculosis screening, Botswana*
| Geographic area | No. index patients† |
No. household members (FR)‡ | No. nearest-neighbors (FR)‡ | No. next-nearest neighbors (FR)‡ | Total subsequent patients (FR)‡ | No. screened to identify 1 TB patient (95% CI)§ | Household contacts that could benefit from TPT¶ | Neighbor contacts that could benefit from TPT¶ | |
|---|---|---|---|---|---|---|---|---|---|
| Gaborone | |||||||||
| A | 123 | 57 (16) | 93 (0) | 47 (2) | 197 (18) | 21 (13–32) | 861 | 3,472 | |
| B | 58 | 19 (4) | 41 (0) | 21 (0) | 81 (4) | 18 (11–28) | 307 | 1,230 | |
| C | 210 | 83 (22) | 146 (8) | 84 (1) | 313 (31) | 16 (9–26) | 1,092 | 4,368 | |
| D | 195 | 58 (10) | 110 (0) | 56 (2) | 224 (12) | 19 (11–30) | 878 | 3,510 | |
| E | 79 | 28 (6) | 46 (0) | 30 (0) | 104 (6) | 11 (5–20) | 253 | 1,011 | |
| F | 129 | 53 (2) | 84 (2) | 51 (2) | 188 (6) | 15 (8–25) | 593 | 2,374 | |
| G | 51 | 14 (0) | 29 (0) | 18 (0) | 61 (0) | 9 (4–17) | 128 | 510 | |
| H | 20 | 5 (0) | 12 (0) | 6 (0) | 23 (0) | 7 (3–14) | 38 | 152 | |
| I | 6 | 2 (0) | 9 (0) | 4 (0) | 15 (0) | 2 (0–7) | 10 | 41 | |
| J | 6 | 2 (0) | 2 (0) | 1 (0) | 5 (0) | 22 (14–33) | 23 | 94 | |
| K |
11 |
6 (0) |
11 (0) |
6 (0) |
23 (0) |
7 (3–14) |
35 |
141 |
|
| Ghanzi District | |||||||||
| Ghanzi | 141 | 83 (57) | 143 (24) | 57 (3) | 283 (84) | 6 (2–16) | 398 | 1,590 | |
| D’kar | 35 | 9 (2) | 14 (8) | 7 (0) | 30 (10) | 11 (5–20) | 86 | 280 | |
| Kuke |
8 |
7 (4) |
9 (0) |
2 (0) |
18 (4) |
8 (3–15) |
28 |
128 |
|
| Total | 1,072 |
426 (123) | 749 (42) | 390 (10) | 1,565 (175) | 16 (9–26) | 4,730 | 18,901 | |
*FR, future related; TB, tuberculosis; TPT, tuberculosis preventive treatment.
†No. index patients is equivalent to the number of standard contact investigations.
‡Future related, i.e., all culture-positive patients with matching M. tuberculosis genotype as an index patient.
§Limits of 95% CI assume a Poisson distribution.
¶Number exposed to bacteriologically confirmed pulmonary TB who do not have TB disease.
Page created: April 16, 2020
Page updated: April 16, 2020
Page reviewed: April 16, 2020
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