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Volume 26, Number 6—June 2020
Research

Failures of 13-Valent Conjugated Pneumococcal Vaccine in Age-Appropriately Vaccinated Children 2–59 Months of Age, Spain

Sergi HernándezComments to Author , Fernando Moraga-Llop, Alvaro Díaz, Mariona F. de Sevilla, Pilar Ciruela, Carmen Muñoz-Almagro, Gemma Codina, Magda Campins, Juan José García-García, Cristina Esteva, Conchita Izquierdo, Sebastià González-Peris, Johanna Martínez-Osorio, Sonia Uriona, Luis Salleras, and Ángela Domínguez
Author affiliations: Agència de Salut Pública de Catalunya, Generalitat de Catalunya, Barcelona, Spain (S. Hernández, P. Ciruela, C. Izquierdo); Hospital Universitari Vall d’Hebron, Barcelona (F. Moraga-Llop, M. Campins, S. González-Peris); Hospital de Nens, Barcelona (A. Díaz); Hospital Sant Joan de Déu Barcelona, Barcelona (M.F. de Sevilla, C. Muñoz-Almagro, J.J. García-García, C. Esteva, J. Martínez-Osorio); Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Spain (M.F. de Sevilla, C. Muñoz-Almagro, J.J. García-García); CIBER de Epidemiología y Salud Pública, Madrid, Spain (P. Ciruela, J.J. García-García, C. Esteva, L. Salleras, Á. Domínguez); Universitat Internacional de Catalunya, Barcelona (C. Muñoz-Almagro); Vall d’Hebron Institut de Recerca, Barcelona (M. Campins, S. Uriona); Universitat de Barcelona, Barcelona (L. Salleras, Á. Domínguez)

Main Article

Table 4

Characteristics of cases of invasive pneumococcal disease caused by serotype 3 in patients 2–59 months of age with vaccine failure or unvaccinated, Catalonia, Spain, 2012–2016*

Variable Vaccine failure, no. (%), n = 16 Unvaccinated, no. (%), n = 20 OR (95% CI) p value
Sex
F 5 (31.3) 6 (30.0) Referent
M
 11 (68.8)
 14 (70.0)
 0.94 (0.23–3.92)
 0.936
Days of admission, mean (SD) 14.69 (9.81) 12.25 (6.07) 1.04 (0.95–1.13) 0.367
ICU days, mean (SD)
 1.00
 3.00 (1.14)
 Not calculable
 0.540
Age group
0–23 mo 3 (18.8) 7 (35.0) Referent
24–59 mo
 13 (81.3)
 13 (65.0)
 2.33 (0.49–11.06)
 0.456
Clinical form
Septic shock 0 1 (5.0) 0 0
Uncomplicated pneumonia 0 2 (10.0) 0 0
Complicated pneumonia 15 (93.8) 17 (85.0) 2.65 (0.25–28.24) 0.613
Mastoiditis
 1 (6.3)
 0
 0
 0
Empyema
No 3 (20.0) 3 (17.6) Referent
Yes
 12 (80.0)
 14 (82.4)
 0.86 (0.15–5.06)
 1.000
Pleural effusion
No 14 (93.3) 13 (76.5) Referent
Yes
 1 (6.7)
 4 (23.5)
 0.23 (0.02–2.36)
 0.338
Necrotizing pneumonia
No 9 (60.0) 13 (76.5) Referent
Yes
 6 (40.0)
 4 (23.5)
 2.17 (0.47–9.95)
 0.450
ICU
No 15 (93.8) 18 (90.0) Referent
Yes
 1 (6.3)
 2 (10.0)
 0.60 (0.05–7.28)
 1.000
Sequelae at discharge
No 13 (81.3) 17 (85.0) Referent
Yes
 3 (18.8)
 3 (15.0)
 1.31 (0.23–7.57)
 1.000
Underlying disease
No 16 (100.0) 19 (95.0)
Yes
 0
 1 (5.0)
PCR diagnosis only
No 1 (6.3) 2 (10.0) Referent
Yes 15 (93.8) 18 (90.0) 1.67 (0.14–20.23) 1.000

*ICU, intensive care unit.

Main Article

Page created: May 18, 2020
Page updated: May 18, 2020
Page reviewed: May 18, 2020
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