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Volume 26, Number 8—August 2020
Dispatch

Increasing Malaria Parasite Clearance Time after Chloroquine Therapy, South Korea, 2000–2016

Seong Yeon Park, Yoon Soo Park, Yoonseon Park, Yee Gyung Kwak, Je Eun Song, Kkot Sil Lee, Shin-Hyeong Cho, Sang-Eun Lee, Hyun-Il Shin, and Joon-Sup YeomComments to Author 
Author affiliations: Dongguk University Ilsan Hospital, Gyeonggi-do, South Korea (S.Y. Park); National Health Insurance Service Ilsan Hospital, Gyeonggi-do (Y.S. Park, Y. Park); Inje University Ilsan Paik Hospital, Gyeonggi-do (Y.G. Kwak, J.E. Song); Myongji Hospital, Gyeonggi-do (K.S. Lee); Korea Centers for Disease Control and Prevention, Chungcheongbuk-do, South Korea (S.-H. Cho, S.-E. Lee, H.-I. Shin); Yonsei University College of Medicine, Seodaemun-gu, Seoul, South Korea (J.-S. Yeom)

Main Article

Table 2

Comparison of clinical features for patients with Plasmodium vivax malaria, according to the dosage of chloroquine, South Korea*

Variable CQ ≥25 mg/kg, n = 361 CQ <25 mg/kg, n = 838 p value
Age, y, mean (±SD)
 42.6 ± 16.2
 41.2 ± 13.2
 0.13
Sex
M 162 (44.9) 706 (84.2) <0.001
F
 199 (55.1)
 132 (15.8)
Positive for underlying disease 66 (18.3) 144 (17.2) 0.35
Primaquine administration 350 (97.0) 831 (99.2) 0.006
Primaquine, mg/kg, mean (±SD)
 0.27 (0.25–0.30)
 0.21 (0.19–0.23)
 <0.001
Smear follow-up
 122 (33.8)
 259 (30.9)
 0.18
Median PCT (IQR), h 62.5 (51.8–81.8) 65.0 (52.0–81.0) 0.19
PCT >48 h 98/122 (80.3) 215/259 (83.0) 0.31
PCT >72 h
 37/122 (30.3)
 91/259 (35.1)
 0.21
Fever 322 (89.2) 752 (89.7) 0.43
Median FCT (IQR), h 37.0 (23.0–54.0) 38.0 (24.0–48.0) 0.02
FCT >48 h 98/295 (33.2) 238/647 (36.8) 0.16
FCT >72 h
 23/295 (7.8)
 78/647 (12.1)
 0.03
Relapse 5 (1.4) 39 (4.7) 0.003

*Values are no. (%) patients/no. treated except as indicated. CQ, chloroquine; FCT, fever clearance time; IQR, interquartile range; PCT, parasite clearance time.

Main Article

Page created: May 05, 2020
Page updated: July 18, 2020
Page reviewed: July 18, 2020
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