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Volume 26, Number 8—August 2020
Dispatch

Increasing Malaria Parasite Clearance Time after Chloroquine Therapy, South Korea, 2000–2016

Seong Yeon Park, Yoon Soo Park, Yoonseon Park, Yee Gyung Kwak, Je Eun Song, Kkot Sil Lee, Shin-Hyeong Cho, Sang-Eun Lee, Hyun-Il Shin, and Joon-Sup YeomComments to Author 
Author affiliations: Dongguk University Ilsan Hospital, Gyeonggi-do, South Korea (S.Y. Park); National Health Insurance Service Ilsan Hospital, Gyeonggi-do (Y.S. Park, Y. Park); Inje University Ilsan Paik Hospital, Gyeonggi-do (Y.G. Kwak, J.E. Song); Myongji Hospital, Gyeonggi-do (K.S. Lee); Korea Centers for Disease Control and Prevention, Chungcheongbuk-do, South Korea (S.-H. Cho, S.-E. Lee, H.-I. Shin); Yonsei University College of Medicine, Seodaemun-gu, Seoul, South Korea (J.-S. Yeom)

Main Article

Table 1

Demographic and clinical data for patients with Plasmodium vivax malaria, by study period, South Korea, 2000–2016*

Variable Years
 p value
2000–2005, n = 404 2006–2010, n = 566 2011–2016, n = 229
Age, y, mean (±SD)
 40.5 ±14.3
 42.5 ±14.0
 41.6 ±14.6
 0.06
Sex
M 279 (69.1) 410 (72.4) 179 (78.2) 0.045
F
 125 (30.9)
 156 (27.6)
 50 (21.8)
Weight, kg, mean (±SD) 66.3 ± 0.57 68.4 ± 0.53 70.5 ± 0.88 <0.001
Smear follow-up
 131 (32.4)
 168 (29.7)
 82 (35.8)
 0.23
Median PCT (IQR), h 63.0 (49.0–82.0) 66.0 (56.3–78.0) 75.0 (52.0–96.5) <0.001
PCT >48 h 100/131 (76.3) 145/168 (86.3) 71/82 (86.6) 0.03
PCT >72 h
 40/131 (30.5)
 61/168 (36.3)
 43/82 (52.4)
 0.005
Fever 347 (85.9) 521 (92.0) 206 (90.0) 0.04
Median FCT (IQR), h 28.0 (14.0–42.0) 43.0 (29.0–59.0) 48.0 (28.0–66.0) <0.001
FCT >48 h 49/279 (17.6) 198/477 (41.5) 87/181 (48.1) <0.001
FCT >72 h
 16/279 (5.7)
 54/477 (11.3)
 29/181 (16.0)
 0.001
CQ, mg/kg, mean (±SD) 23.5 ±5.0 22.9 ±4.4 22.1 ±4.8 0.001
CQ <25 mg/kg
 278 (68.8)
 383 (67.7)
 177 (77.3)
 0.02
Primaquine, mg/kg, mean (±SD) 0.23 ± 0.06 0.24 ± 0.06 0.29 ± 0.12 <0.001
Primaquine <0.25
 265/373 (71.0)
 343/543 (63.2)
 114/221 (51.6)
 <0.001
Relapse 9/394 (2.3) 20/541 (3.7) 10/220 (4.5) 0.20

*Values are no. (%) patients/no. treated except as indicated. CQ, chloroquine; FCT, fever clearance time; IQR, interquartile range; PCT, parasite clearance time.

Main Article

Page created: May 05, 2020
Page updated: July 18, 2020
Page reviewed: July 18, 2020
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