Volume 26, Number 8—August 2020
CME ACTIVITY - Research
Sporadic Creutzfeldt-Jakob Disease among Physicians, Germany, 1993–2018
Peter Hermann1
, Johannes Treig1, Steffen Unkel, Stefan Goebel, Timothy Bunck, Martha Jünemann, Tim Friede, and Inga Zerr
, Johannes Treig1, Steffen Unkel, Stefan Goebel, Timothy Bunck, Martha Jünemann, Tim Friede, and Inga Zerr
Table 1
Characteristics of sCJD patients, Germany, 1993–2018*
| Variable | Cohort A | Cohort B | Validation cohort |
|---|---|---|---|
| Time period |
1993 Jun–2005 Dec |
2006 Jan–2016 Dec |
2017 Jan–2018 Dec |
| Total, no. (%) | 1,250 (100) | 1,491 (100) | 234 (100) |
| Definite sCJD | 711 (57) | 491 (33) | 59 (25) |
| Probable sCJD |
539 (43) |
1,000 (67) |
175 (75) |
| Mean age, y (range) |
66 (35–90) |
68 (37–93) |
68 (41–91) |
| Sex | |||
| F | 731 (58) | 769 (52) | 118 (50) |
| M |
519 (42) |
722 (48) |
116 (50) |
| Codon 129, no. (%) | |||
| MM | 693 (67) | 322 (55) | 8 (53)† |
| MV | 180 (17) | 134 (23) | 7 (47)† |
| VV |
166 (16) |
125 (22) |
0 |
| Occupation known, no. (%) |
1,093 (87) |
439 (29) |
70 (30) |
| Physicians, no. (% of all patients, % of known occupation) | 4 (0.3, 0.4) | 13 (0.9, 3) | 5 (2.1, 7.1) |
*MM, methionine homzygosity; MV, heterozygosity; sCJD, sporadic Creutzfeldt-Jakob disease; VV, valin homozygosity.
†Since 2015, codon 129 analyses were not regularly performed during neuropathologic investigation.
1These authors contributed equally to this article.
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